Development of Gas-Chromatographic Method for Simultaneous Determination of Cannabinoids and Terpenes in Hemp

An original gas chromatographic method has been developed for simultaneous determination of major terpenes and cannabinoids in plant samples and their extracts. The main issues to be addressed were the large differences in polarity and volatility between both groups of analytes, but also the need for an exhaustive decarboxylation of cannabinoid acidic forms. Sample preparation was minimised, also by avoiding any analyte derivatisation. Acetone was found to be the most appropriate extraction solvent. Successful chromatographic separation was achieved by using a medium polarity column. Limits of detection ranged from 120 to 260 ng/mL for terpenes and from 660 to 860 ng/mL for cannabinoids. Parallel testing proved the results for cannabinoids are comparable to those obtained from established HPLC methods. Despite very large differences in concentrations between both analyte groups, a linear range between 1 and 100 µg/mL for terpenes and between 10 and 1500 µg/mL for cannabinoids was determined.

Unusual response to environmental polarity in a nonlinear-optical benzylidene-type chromophore containing a 1,3-bis(dicyanomethylidene)indane acceptor fragment

The torsion angle between the planes of donor and acceptor fragments in 1,3-bis(dicyanomethylidene)indane based benzylidene increases with the surrounding medium polarity.

Sorption and catalysis by robust microporous metalloporphyrin framework solids

Two isostructural metalloporphyrin framework solids have been synthesized. Both frameworks contains manganese(III) metal complexes of trans-dicarboxylateporphyrins whose peripheralcarboxylates coordinate the edges of tetrahedral Zn4O[Formula: see text] clusters; the two metalloporphyrins explored are Mn(III) and Co(II). The cubic interpenetrated frameworks have 72% free volume and 4 × 7 Å averaged size pores. The evacuated frameworks are robust and retain a structure open to the sorption of substrates with medium polarity. The manganese porphyrin framework catalyzes the hydroxylation of cyclic and linear alkanes with iodosylbenzene as oxidant in a size- and polarity-selective manner. In addition, the catalysis was found to occur within the pores, making this a rare case of porphyrin framework solid with interior catalysis.