Facile Preparation of Aryl Nitriles from Aryl Aldehydes in PEG-DME 250

: A facie and efficient method for one-pot transformation of aryl aldehydes to aryl nitriles using hydroxylamine hydrochloride and phosphorus tribromide in PEG-DME 250 is reported. The conversion of various aryl aldehydes to the corresponding aryl nitriles occurred smoothly in high yields under the present reaction conditions.

Dichlorophosphoranides Stabilized by Formamidinium Substituents

Dichlorophosphoranides featuring N,N-dimethyl-N′-arylformamidine substituents were isolated as individual compounds. Dichlorophosphoranide 9 was prepared by the multicomponent reaction of C-trimethylsilyl-N,N-dimethyl-N′-phenylformamidine and N,N-dimethyl-N′-phenylformamidine with phosphorus trichloride. Its molecular structure derived from a single-crystal X-ray diffraction was compared to the analogous dibromophosphoranide prepared previously by us by the reaction of phosphorus tribromide with N,N-dimethyl-N′-phenylformamidine. It was shown that a chlorophosphine featuring two N,N-dimethyl-N′-mesitylformamidine substituents reacted with hydrogen chloride to form dichlorophosphoranide 11. Its molecular structure was also determined by X-ray analysis and compared with that of closely related dichlorophosphoranide C.

N-heterocyclic carbene induced reductive coupling of phosphorus tribromide. Isolation of a bromine bridged P–P bond and its subsequent reactivity

Thermal treatment of a 1:1 adduct of phosphorus tribromide and 1,3-bis(2,6-diisopropylphenyl)-imidazol-2-ylidene (IPr) results in the formation of a reduced phosphorus-containing dimer, which can be employed to access a range of low oxidation state compounds.

A Scalable and Cycle Process for 2,4-Dibromopyrimidine

A scalable and cycle process for 2,4-dibromopyrimidine is developed by bromination of 2,4-dichloropyrimidine using phosphorus tribromide. Compared with the literature reported before, the amount of bromination agent-phosphorus tribromide has been greatly reduced and purification of the product by recrystallization is realized. The total yield of 2,4-dibromopyrimidine can reach to 85.4%. The process is more suitable for scale-up production.