peptide hydrolase
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Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer’s Disease: A Sign of Defective Proteostasis?

2017 ◽  
Vol 60 (3) ◽  
pp. 1097-1106 ◽  
Author(s):  
Gianna Palmieri ◽  
Ennio Cocca ◽  
Marta Gogliettino ◽  
Roberta Valentino ◽  
Menotti Ruvo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Peptide Hydrolase

Screening of β-hairpin peptide-engrafted 1,2,3-triazoles to identify APEH enzyme inhibitors

RSC Advances ◽  
2015 ◽  
Vol 5 (13) ◽  
pp. 9965-9972 ◽  
Author(s):  
A. Sandomenico ◽  
V. Celentano ◽  
L. D. D'Andrea ◽  
G. Palmieri ◽  
M. Ruvo
Keyword(s):  
Click Chemistry ◽  
Enzyme Inhibitors ◽  
Proteasome Activity ◽  
Inhibition Activity ◽  
Peptide Hydrolase

Peptide-engrafted triazoles, obtained via click chemistry, drive the inhibition activity toward Acyl Peptide Hydrolase (APEH), a modulator of the proteasome activity.

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