Erectile Function, Sexual Satisfaction, and Cognitive Decline in Men from Midlife to Old Age

We investigated how changes in erectile function and sexual satisfaction relate to cognitive decline in men from midlife into early old age. This is a major transitional period for increased incidence of erectile function and for cognitive decline. We examined 833 men from the Vietnam Era Twin Study of Aging whose mean ages were 56, 61, and 68 at the time of assessment. Erectile function and sexual satisfaction were measured using scores from the International Index of Erectile Function. Individuals with erectile dysfunction at baseline were excluded. Cognitive performance was measured using factor scores for separate domains of episodic memory, executive function, and processing speed. We tested linear mixed models hierarchically adjusted for demographics, sexual activity, as well as physical and mental health confounders to examine how changes in erectile function and sexual satisfaction related to changes in cognitive function. Declines in erectile function were associated with declines in episodic memory (p=.004, d=.25), while declines in sexual satisfaction were associated with declines in processing speed (p=.006, d=.19). Decreasing erectile function and sexual satisfaction may be indicative of individuals also likely to be facing cognitive decline. Possible mechanisms accounting for these changes may include white matter microvascular disease and/or various lifestyle influences. Discussing and tracking sexual health with middle aged men may be a crucial step in identifying those likely to face cognitive decline.

The genetic etiology of longitudinal measures of predicted brain ageing in a population-based sample of mid to late-age males

Despite their increasing application, the genetic and environmental etiology of global predicted brain ageing (PBA) indices is unknown. Likewise, the degree to which genetic influences in PBA are longitudinally stable and how PBA changes over time are also unknown. We analyzed data from 734 men from the Vietnam Era Twin Study of Aging with repeated MRI assessments between the ages 52 to 72 years. Biometrical genetic analyses revealed significant and highly correlated estimates of additive genetic heritability ranging from 59% to 75%. Multivariate longitudinal modelling revealed that covariation between PBA at different timepoints could be explained by a single latent factor with 73% heritability. Our results suggest that genetic influences on PBA are detectable in midlife or earlier, are longitudinally very stable, and are largely explained by common genetic influences.

Breaking the Eleventh Commandment

A closer look at Representative Paul N. “Pete” McCloskey’s decision to challenge Richard Nixon for the 1972 Republican presidential nomination due to Nixon’s failure to bring the Vietnam conflict to a conclusion reveals some intriguing aspects of the relationship between domestic politics and foreign policy during the U.S. experience in Vietnam. In breaking the GOP’s “Eleventh Commandment”—the exhortation to not speak ill of fellow Republicans—McCloskey acted on the courage of his convictions in opposing the war and his party’s sitting president. For McCloskey, Vietnam transcended politics; it was a moral issue on which he was willing to sacrifice his political career—unlike most other members of Congress and politicians in successive administrations during the Vietnam era. Moreover, McCloskey’s failure to gain traction with voters in the GOP primaries with his antiwar stance presaged George McGovern’s struggles against Nixon in the fall campaign in 1972.