stannous fluoride
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Author(s):  
Sampada Dahake ◽  
Priyanka Paul Madhu ◽  
Amit Reche ◽  
Kumar Gaurav Chhabra ◽  
Simran Kriplani ◽  
...  

Background: The key goal of the study is to find out the effectiveness of anacardic acid and the stannous fluoride as an anti erosive agent. Objectives: To evaluate the erosive effect of Bio vinegar and antierosive effect of Anacardic acid and Stannous Fluoride.    Methodology: The extracted teeth were collected for in vitro study. Three solutions were selected Bio vinegar, Anacardic acid, Fluoride to treat the extracted teeth to study and compare the anti-erosive effect. The sets of extracted teeth of ten each were grouped to be treated with different solutions. The set was immersed in Bio vinegar for 8 hours for erosive action. The second set of ten extracted teeth were immersed in anacardic acid for four days. The same set of teeth were treated with vinegar for 8 hours. The cross sectional view of stained teeth was viewed under Scanning Electron Microscope. The third set of teeth was immersed in stannous fluoride for four days and then treated with Bio vinegar for 8 hours. The cross sectional view of stained teeth was viewed under Scanning Electron Microscope. A comparison of anti-erosive effect of anacardic acid and stannous fluoride were studied under Scanning Electron Microscope. Expected Results: Determining a better effectiveness of Anacardic acid antierosive agent than stannous fluoride. Conclusion: Reduction in the level of erosion by the application of anacardic acid and stannous fluoride on extracted teeth exposed to carbonated drinks and assessment of erosive effect of carbonated drink on tooth.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Amina Acherkouk ◽  
Nisha Patel ◽  
Andrew Butler ◽  
Pejmon Amini

Abstract Background This examiner-blind, stratified, parallel study aimed to evaluate the anti-gingivitis efficacy of a non-aqueous (anhydrous) 0.454% w/w stannous fluoride toothpaste (‘Test’) versus a sodium monofluorophosphate toothpaste (‘Control’) in people with clinically-confirmed mild-moderate gingivitis. Plaque-induced gingivitis can progress to irreversible periodontitis if left untreated. This can be controlled by an effective oral hygiene regimen such as one including toothbrushing with a toothpaste containing the chemotherapeutic agent stannous fluoride. Long-term studies over 4–12 weeks have shown the efficacy of stannous fluoride; however, shorter term studies are needed to examine if the effects on measures of gingivitis and plaque control occur sooner. Methods Eligible participants were randomised to 3 weeks’ twice-daily brushing (for 1 min) with Test or Control toothpastes. The primary efficacy variable was between-treatment difference in Bleeding Index (BI) at 3 weeks; secondary variables were between-treatment differences in number of bleeding sites, modified Gingival Index (MGI), and Turesky modification of the Quigley–Hein Plaque Index (TPI) at Weeks 2 and 3. Results A statistically significant (p < 0.0001) lower BI score was reported for Test (n = 65) versus Control (n = 65) groups at Week 2 (mean difference: − 0.07 [95% CI − 0.9, − 0.05]; 32.7% difference) and Week 3 (mean difference: − 0.06 [95% CI − 0.8, − 0.04]; 29.2% difference). The Test group also demonstrated statistically significant lower (all p < 0.0001 versus Control) number of bleeding sites (Weeks 2/3 mean difference [95% CI]: − 10.04 [− 12.3, − 7.5]/ − 8.2 [− 11.1, − 5.3] sites; 33.0%/29.3% difference); MGI score (Weeks 2/3 mean difference [95% CI]: − 0.09 [− 0.13, − 0.06]/ − 0.10 [− 0.14, − 0.06]; 4.3%/4.7% difference); overall TPI score (Weeks 2/3 mean difference [95% CI]: − 0.45 [− 0.55, − 0.35/ − 0.42 [− 0.53, − 0.30] difference; 16.0%/15.1% difference) and interproximal TPI score (Weeks 2/3 mean difference [95% CI]: − 0.42 [− 0.52, − 0.30]/ − 0.41 [− 0.52, − 0.29]; 14.6%/14.1% difference). Both toothpastes were generally well tolerated. Conclusion Three weeks’ twice-daily brushing with the 0.454% w/w stannous fluoride Test toothpaste compared to the Control toothpaste led to statistically significant lower gingival bleeding, gingival inflammation and plaque levels in adults with mild-moderate gingivitis. These results indicate that plaque and gingivitis-reducing benefits of 0.454% w/w stannous fluoride may be seen from 2 weeks’ use. Trial registration ClinicalTrials.gov Identifier: NCT04050722; 08/08/2019.


2021 ◽  
Vol 105 ◽  
pp. 103566
Author(s):  
Nicola X. West ◽  
Tao He ◽  
Yuanshu Zou ◽  
Joe DiGennaro ◽  
Aaron Biesbrock ◽  
...  

2021 ◽  
Vol 35 ◽  
Author(s):  
Giorgio Aldigueri TRENTIN ◽  
Laura Teixeira MENDES ◽  
Bruna Soares da SILVA ◽  
Luciano CASAGRANDE ◽  
Fernando Borba de ARAUJO ◽  
...  

2020 ◽  
Vol 8 (11) ◽  
pp. 991-1003
Author(s):  
Isha Bisla ◽  

Dental caries is a most common disease that affects large number of people. It is a worldwide public health problem, affecting numerous urban and rural communities. White-spot lesions (WSL) are the earliest macroscopic evidence of enamel caries. Typically, the enamel surface layer stays intact during subsurface demineralization, but, without treatment, will eventually collapse into a full cavity. Near-neutral pH of saliva is endowed with a natural buffering capacity. Natural demineralization of tooth at an early stage is reversed by saliva, which contains calcium ions, phosphate ions, buffering agents, fluoride, and other substances. The strategy for aided remineralisation is to have ions directly delivered to where and when they are needed the most. Several mechanisms are available for aided remineralisation. The most well known is the delivery of topical and systemic fluoride, which has been proven to be a highly effective measure for prevention of caries. However limitations and risks associated with the use of fluoride as a remineralising agent fuelled the need to develop newer non-toxic techniques that deliver calcium and phosphate ions directly into subsurface lesion and/or boost remineralising properties of saliva. Encouraging microscopic changes in the demineralized enamel surface following the treatment with different concentration of metal salts, involving zinc, strontium, magnesium, in addition to stannous fluoride, many metal salts are in use for the treatment of dental caries. Microscopic examination was conducted on teeth samples before and after pH-cycling procedure and following the treatment with the selected metal salt under polarized microscope (100X). The best obvious remineralisation was found following treatment with stannous fluoride, followed by zinc chloride. The stannous fluoride was the best in the remineralisation of initial caries, results for other metals seem to be promising if used for prevention of dental caries. Mineralization of teeth is determined by major inorganic elements as calcium, phosphorous in addition to other elements that occur in traces within tooth structure (Thylstrup and Fejerskov, 1996 Murry, 1996 Peter, 2004). Fluoride now a day is widely used either systemically or topically to increase resistance of teeth surface, it has been well documented as a major contributing factor in the decline of the incidence and severity of dental caries in many countries (Murry, 1996 Curzon,1999).So far fluoride has been considered to play an almost unique role in the prevention of dental caries however there is no reason to dismiss the role of other elements as being potential cariostatic agents. Different concentrations of different metal ions as zinc and copper have been tested for better effect on remineralisation in vitro (Dedhiya, et al., 1974 Fang et al., 1980). However controversy is present in the literature concerning their effectiveness in prevention of dental caries when used topically at effective concentrations (Torredo et al., 2004 Elzbieta et al., 2008 Curzon, 1983).


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