Comparative capabilities of the speckle-tracking echocardiography technologiesin two-dimensional and three-dimensional modes in the detection of subclinical cardiotoxicity in patients with breast cancer

Aim.The study was to assess the deformation properties of the left ventricle (LV) myocardium in patients with breast cancer initially and after anthracycline chemotherapy according to 2D and 3D speckle-tracking echocardiography (STE). Material and methods.the study included 99 patients with triple negative breast cancer with hypertensionandnormotension. All patients underwent standard transthoracic echocardiography with assessment of systolic function of the LV. To assess the indicator of global longitudinal strain (GLS), as a marker of cardiotoxicity, STE was used in two-and three-dimensional modes. In the three-dimensional STE mode, a new strain parameter, the global area strain (GAS) was evaluated. Results.The study showed that in patients with breast cancer for a more accurate assessment of LV systolic function (ejection fraction) it is advisable to use 3D-echocardiography. A comparative analysis revealed statistically significantly lower values of the GLS according to the three-dimensional mode of STE compared to two-dimensional. The study also evaluated a new strain parameter GAS (%). In patients with breast cancer during ROC analysis with a value of -14.0, the GAS indicator for the development of subclinical cardiotoxicity showed a sensitivity of 81.5% and a specificity of 73.3%. Сonclusion.the advantage of the STE in the three-dimensional mode, in contrast to the two-dimensional mode, is the simultaneous and more accurate assessment of LVEF. The value of the additional parameter of LV deformation the area of deformation requires further study.

Computer Analysis of Thermomechanical State of Sealing Steel Lining for Containment of NPPs with VVER-1000/V-320 in Emergencies

Computer analysis of thermomechanical state of the sealing steel lining under relevant extreme hazards has been performed to define the possibility and scope of loss of integrity of sealing steel lining, in particular the possibility of losing of the confining function by the NPP reactor compartment containment under emergency conditions. The study gave an opportunity to obtain functions of stress strain parameter evolution function in reinforced concrete and sealing steel lining depending on changes in emergency temperature and pressure in the reactor compartment. The paper assessed the margin of sealing steel lining bearing capacity.