neurotoxic pesticides
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2022 ◽  
Vol 21 (1) ◽  
Author(s):  
Bernard Laubscher ◽  
Manuel Diezi ◽  
Raffaele Renella ◽  
Edward A. D. Mitchell ◽  
Alexandre Aebi ◽  
...  

Abstract Background Neonicotinoids (NN) are selective neurotoxic pesticides that bind to insect but also mammal nicotinic acetycholine receptors (nAChRs). As the most widely used class of insecticides worldwide, they are ubiquitously found in the environment, wildlife, and foods, and thus of special concern for their impacts on the environment and human health. nAChRs are vital to proper brain organization during the prenatal period and play important roles in various motor, emotional, and cognitive functions. Little is known on children’s contamination by NN. In a pilot study we tested the hypothesis that children’s cerebro-spinal fluid (CSF) can be contaminated by NN. Methods NN were analysed in leftover CSF, blood, and urine samples from children treated for leukaemias and lymphomas and undergoing therapeutic lumbar punctions. We monitored all neonicotinoids approved on the global market and some of their most common metabolites by ultra-high performance liquid chromatography-tandem mass spectrometry. Results From August to December 2020, 14 children were consecutively included in the study. Median age was 8 years (range 3–18). All CSF and plasma samples were positive for at least one NN. Nine (64%) CSF samples and 13 (93%) plasma samples contained more than one NN. Thirteen (93%) CSF samples had N-desmethyl-acetamiprid (median concentration 0.0123, range 0.0024–0.1068 ng/mL), the major metabolite of acetamiprid. All but one urine samples were positive for ≥ one NN. A statistically significant linear relationship was found between plasma/urine and CSF N-desmethyl-acetamiprid concentrations. Conclusions We have developed a reliable analytical method that revealed multiple NN and/or their metabolites in children’s CSF, plasma, and urine. Our data suggest that contamination by multiple NN is not only an environmental hazard for non-target insects such as bees but also potentially for children.


Author(s):  
Breana Bennett ◽  
Tomomi Workman ◽  
Marissa N. Smith ◽  
William C. Griffith ◽  
Beti Thompson ◽  
...  

The exposome provides a conceptual model for identifying and characterizing lifetime environmental exposures and resultant health effects. In this study, we applied key exposome concepts to look specifically at the neurodevelopmental pesticide exposome, which focuses on exposures to pesticides that have the potential to cause an adverse neurodevelopmental impact. Using household dust samples from a children’s agricultural cohort located in the Yakima Valley of Washington state, we identified 87 individual pesticides using liquid chromatography-tandem mass spectrometry. A total of 47 of these have evidence of neurotoxicity included in the Environmental Protection Agency (EPA) (re)registration materials. We used a mixed effects model to model trends in pesticide exposure. Over the two study years (2005 and 2011), we demonstrate a significant decrease in the neurodevelopmental pesticide exposome across the cohort, but particularly among farmworker households. Additional analysis with a non-parametric binomial analysis that weighted the levels of potentially neurotoxic pesticides detected in household dust by their reference doses revealed that the decrease in potentially neurotoxic pesticides was largely a result of decreases in some of the most potent neurotoxicants. Overall, this study provides evidence that the neurodevelopmental pesticide exposome framework is a useful tool in assessing the effectiveness of specific interventions in reducing exposure as well as setting priorities for future targeted actions.


2018 ◽  
Vol 32 (8) ◽  
pp. 1921-1930 ◽  
Author(s):  
Tobias Pamminger ◽  
Christina Botías ◽  
Dave Goulson ◽  
William O. H. Hughes

2018 ◽  
Vol 196 ◽  
pp. 79-89 ◽  
Author(s):  
Chiara Gambardella ◽  
Daniela Nichino ◽  
Camillo Iacometti ◽  
Sara Ferrando ◽  
Carla Falugi ◽  
...  

2015 ◽  
Vol 355 (1) ◽  
pp. 99-107 ◽  
Author(s):  
Sarah E. Lacher ◽  
Kasse Skagen ◽  
Joachim Veit ◽  
Rachel Dalton ◽  
Erica L. Woodahl

2014 ◽  
Vol 42 ◽  
pp. 24-32 ◽  
Author(s):  
M.P. Gatto ◽  
M. Fioretti ◽  
G. Fabrizi ◽  
M. Gherardi ◽  
E. Strafella ◽  
...  

2013 ◽  
Vol 48 (7) ◽  
pp. 559-569 ◽  
Author(s):  
Saheli Pradhan ◽  
Indrani Roy ◽  
Gopal Lodh ◽  
Prasun Patra ◽  
Samrat Roy Choudhury ◽  
...  

2011 ◽  
Vol 29 (3) ◽  
pp. 667-677 ◽  
Author(s):  
David A. Jett

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