The convergence of five river systems in far western Kentucky significantly influenced the progress of human settlement and activity over the past several thousand years in the area now known as the Jackson Purchase. The geological history of the Jackson Purchase set the stage for the development of unique land- and waterscapes with natural histories very different from the rest of Kentucky. The Ohio, the Mississippi, the Cumberland, and the Tennessee Rivers define the present boundaries of the Purchase area, and the smaller Clarks River provides the major drainage through its midsection. Major geological, hydrological, and human historical events including the New Madrid earthquakes, Civil War, floods, water-borne diseases, the ever-changing focus of agriculture and industry, and 20th century dam building, including construction of two major hydroelectric reservoirs (Kentucky Lake and Lake Barkley) all affected peoples’ choices of where to live and how to use the land and water resources of the region.Today, western Kentuckians are actively engaged in preserving the quality of the region’s water resources because of the recreational, agricultural, industrial, transportation, and ecological services they provide.