The hydrogen bond is a very important interaction which demonstrates a wide variety in strength and shape and can be held as the central point in the crystal engineering process of a great number of compounds. In the formation of salts versus co-crystals, pH control is necessary in order to obtain one form or the other. In the pharmaceutical industry which is actively developing Active Pharmaceutical Ingredients (APIs) with desirable properties, such consideration is of major concern. In 2012, Cruz-Cabeza[1] carried out a survey of over 6 000 structures and found a linear relationship between ΔpKa and the probability of proton transfer for the pKa range of -1 to +4. The cross-over point was determined to be at ΔpKa = 1.3. Beyond this point the probability to obtain a salt rather than a co-crystal is higher than 50%. Parallel to this work, Gilli & Gilli[2] have built a sliding rule which predicts the strength of a Donor – Acceptor hydrogen bond based on the ΔpKa of the system. Their device predicts the formation of salts if ΔpKa > 3, and co-crystals when ΔpKa < -3. In their paper, Gilli & Gilli point out that the interval of ΔpKa matching should be shifted by 1.5 units when interpreting crystal structures,[3] which agrees with the findings of Cruz-Cabeza. In this work we discuss the bonding of 22 structures made up of acid-base pairs which either form salts or co-crystals. A series of five substituted benzoic acids with 10 substituted pyridines and quinolines have been crystallized so that their ΔpKa, defined as pKa(base) – pKa(acid), spans the range -1.14 to +4.16. This covers the `uncertainty' region for the formation of salt versus co-crystals. Although most of our results confirmed that structure formation of co-crystal versus salt parts at ΔpKa ≍ 2, we report here a structure that does not follow the general rule and serves as a cautionary tale.
The Effectiveness of Hot Fomentation with Epsom Salt Versus Common Salt on Knee Joint Pain among Elderly in the Selected Old Age Home of Pune City
