قاعدة العموم و الخصوص و تطبيقاتها في تفسير الإمام الطبري

is one of the intentions of Sharia’, through which the Sharia Laws and legal constructions are shown in directing the Qura’nic text, where it is expressed in the general rule, then later comes what limits it concerning the “Private” and “the public”, which comes from the textual proofs aspects and the consensus proofs and the moral proofs. The research is an explanation for a great Imam of the Interpretation Savants in takling the subject: “The private” and “the public” in Holy Qura’n. His view was clear in this research in taking the verses of Holy Qura’n in the general sense, regardless to the private sense specifying that the Holy Qura’n is the Sharia’ of the Seal Message which comprises .all recents and recent developments in the course of time. Moreover the research explains an important side from the sides of inimitability of Holy Qura’n in legislation, language and comprehensiveness

SARS-CoV-2 risk taxation model and validation based on large scale Dutch test-events

In response to the outbreak of SARS-CoV-2 many governments decided in 2020 to impose lockdowns. Although the package of measures which constitute such lockdowns differs between countries, it is a general rule that contacts between people, and especially in large groups of people, are avoided or prohibited. The main reasoning behind these measures is preventing that healthcare systems become overloaded. As of 2021 vaccines against SARS-CoV-2 are available, but these do not guarantee 100% risk reduction and it will take a while for the world to reach a sufficient immune status. This raises the question whether and under which conditions events like theater shows, conferences, professional sports events, concerts and festivals can be organized. The current paper presents a COVID-19 Risk taxation method for (large scale) events. This method can be applied to events to define an alternative package of measures replacing generic social distancing.

Using machine learning to predict optimal electromagnetic induction instrument configurations for characterizing the shallow subsurface

Electromagnetic induction (EMI) is used widely for hydrological and other environmental studies. The apparent electrical conductivity (ECa), which can be mapped efficiently with EMI, correlates with a variety of important soil attributes. EMI instruments exist with several configurations of coil spacing, orientation, and height. There are general, rule-of-thumb guides to choose an optimal instrument configuration for a specific survey. The goal of this study was to provide a robust and efficient way to design this optimization task. In this investigation, we used machine learning (ML) as an efficient tool for interpolating among the results of many forward model runs. Specifically, we generated an ensemble of 100 000 EMI forward models representing the responses of many EMI configurations to a range of three-layer subsurface models. We split the results into training and testing subsets and trained a decision tree (DT) with gradient boosting (GB) to predict the subsurface properties (layer thicknesses and EC values). We further examined the value of prior knowledge that could limit the ranges of some of the soil model parameters. We made use of the intrinsic feature importance measures of machine learning algorithms to identify optimal EMI designs for specific subsurface parameters. The optimal designs identified using this approach agreed with those that are generally recognized as optimal by informed experts for standard survey goals, giving confidence in the ML-based approach. The approach also offered insight that would be difficult, if not impossible, to offer based on rule-of-thumb optimization. We contend that such ML-informed design approaches could be applied broadly to other survey design challenges.

Temporal variation of patch connectivity determines biodiversity recovery from recurrent disturbances

Understanding the capacity of ecological systems to withstand and recover from disturbances is a major challenge for ecological research in the context of environmental change. Disturbances have multi-scale effects: they can cause species extinctions locally and alter connectivity between habitat patches at the metacommunity level. Yet, our understanding of how disturbances influence landscape connectivity remains limited. To fill this gap, we develop a novel connectivity index that integrates the temporal variation of patch connectivity induced by disturbances, which can be applied to any spatially-structured habitat. We then combine this index with a metacommunity model to specifically investigate biodiversity recovery from drying events in river network metacommunities. We demonstrate that patch connectivity explains variations of species richness between groups of organisms with contrasting dispersal modes and captures the effect of drying intensity (i.e., fraction of patches that dry-up) and drying location on community recovery. As a general rule, loss of patch connectivity decreases community recovery, regardless of patch location in the river network, dispersal mode, or drying intensity. Local communities of flying organisms maintained higher patch connectivity in drying river networks compared to organisms with strictly aquatic dispersal, which explained the higher recovery capacity of this group from drying events. The general relationship between patch connectivity and community recovery we found can be applied to any spatial network subject to temporal variation of connectivity, thus providing a powerful tool for biodiversity management in dynamic landscapes.

An Overview of the Civil Procedure and Court System of Netherlands

When it comes to Dutch law, the initiation of civil litigation, there are just a few cases in the Netherlands. This is due to the harmonized Dutch culture. Therefore, compared to other European countries, the number of lawyers and judges per capita in the Netherlands is small. In this scientific paper, we will make an overview of the civil judicial organization, the types of civil proceedings, the obligation to represent the civil cases in the court through a lawyer, legal aid and also in more detail we will focus on the main stages of the civil trial as well as the conditions that must be met before initiating civil proceedings. We will analyze in detail the fact that in the Dutch Law, the defendant may deny the right to judicial reconciliation with the plaintiff, before initiating the proceedings and that it is also preferable in Dutch Law, that the opposing party is summoned to fulfill its obligations within a certain period. If without respecting this method, the court procedure is initiated, the court costs may be attributed to the initiator of the procedure, i.e the plaintiff. Except for proceedings before judges from subordinate regions in Dutch law, the general rule is that the proceedings must be presided over by the plaintiff's attorney (procurator litis) and by a lawyer selected from the list of attorneys registered with the Association. In this scientific paper, we will also pay special attention to the temporary legal protection and special procedures and we will also focus on the judgments and legal remedies in Dutch law.

Retroactivity in international treaty law

Problem setting. Due to the fact that the constitutional norms determine the status of an international treaty, the binding nature of which has been approved by the parliament as part of national legislation, it is important to study the temporal effect of international treaties, namely their retroactivity. In general, the Vienna Convention contains a provision according to which an international treaty has no retroactive effect in respect of the States which are parties to it, except where the intention to give retroactive effect to the treaty follows from the treaty itself or the agreements of its parties. These exceptions to the general rule indicate the non-absoluteness of the latter, so it is appropriate to study the factors that determine the existence of retroactive agreements, as well as controversial and controversial issues that arise in this regard. Analysis of recent researches and publications. Scholars such as S.N. Ivanov, RA Kalamkaryan, M.A. Kapustina, II Lukashuk, OV Pushnyak and others. However, this area needs further study and analysis, given the existence of exceptions to the general provision on the lack of retroactive effect of international agreements. Target of research. Тo consider the conditions under which an international treaty has retroactive effect, to investigate the factors influencing the decision to grant retroactive effect and the issues arising in connection with the retroactivity of international treaties. Article’s main body. This study examines the non-absoluteness of the provision on the absence of retroactive effect of international agreements. Among the reasons that encourage states to anticipate retroactive effect – the interpretive or additional nature of the international agreement or the need to resolve the situation that arose before its conclusion. It should be emphasized that some agreements have retroactive effect by virtue of their object, which provides this retroactive effect, as agreed by the parties, although not explicitly stated in the contract. It is also not uncommon for certain rights and obligations to arise not because of an international treaty that has not yet entered into force, but because of customary norms that are enshrined in it. Conclusions and prospects for the development. The principle of no retroactive effect of an international agreement is not absolute. In each case, the reasons for the application of retroactivity must be decided by a judicial authority in the process of interpreting the contractual obligations. An important role in the possibility of retroactive application of an international treaty is played by its object or the co-existing customary norms of international law and the principles recognized by civilized nations as binding.

The various dose-dependent effect of selenium oxide and copper oxide nanoparticles in vitro and application of the hormesis paradigm

Introduction. In vitro studies on a culture of cardiomyocytes have shown that dose-response relationships could be monotonic for some effects and non-monotonic for others. In this work, we wanted to demonstrate that these features of the dose-response relationship are a general pattern. Materials and methods. In vitro experiments were conducted on the culture of human fibroblast-like cells FLECH-104. The cytotoxicity of spherical nanoparticles of selenium oxide (SeO-NP) and copper oxide (CuO-NP) was studied with an average diameter of 51 ± 14 nm and 21 ± 4 nm, respectively. Results. SeO-NP and CuO-NP were cytotoxic for human fibroblast-like cells, as judged by a decrease in ATP-dependent luminescence. In this case, the cytotoxicity of CuO-NP was somewhat more substantial than the SeO-NP one. Our experiment revealed doses that cause both cell hypertrophy and a decrease in the size of cells and nuclei. Discussion. We observed both monotonic and different variants of the non-monotonic dose-response relationship. For the latter, it was possible to construct adequate mathematical expressions based on the generalized hormesis paradigm that we had considered earlier concerning the CdS-NP and PbS-NP cytotoxicity for cardiomyocytes. Conclusion. The general rule is the variability of the dose-response dependence types manifested in different cytotoxic effects of nanoparticles.

THE CONSTITUTIONAL RIGHT OF ACCESS TO PUBLIC SERVICE ON THE SAME TERMS AND THE ISSUE OF EMPLOYING A LOCAL GOVERNMENT EMPLOYEE FOR THE PERIOD OF REPLACEMENT – REFLECTIONS ON THE TOPIC

The study attempts to analyse the legal regulation concerning the employment of a local government employee for a replacement period from the point of view of the constitutional right of access to public service on equal terms. The study refers jurisprudence (in particular to the decisions of the Constitutional Tribunal). This solution is an exception to the general rule of competitive and open recruitment. It should be emphasised that the right resulting from Article 60 of the Constitution of the Republic of Poland is not absolute. Hence the introduction of „exceptions” is permissible. However, this should be supported by another constitutional value. The analysed statutory regulation is only temporary (for the period of excused absence of an employee). It is based on the principle of efficiency and reliability of public institutions resulting from the preamble to the Constitution of the Republic of Poland. The purpose of this solution is to ensure the effective performance of tasks by the local government.

The Case Against Censoring of Progression-Free Survival in Cancer Clinical Trials – A Pandemic Shutdown as an Illustration

Missing data may lead to loss of statistical power and introduce bias in clinical trials. The ongoing Covid-19 pandemic has had a profound impact on patient health care and on the conduct of cancer clinical trials. Restricted access to sites, medication and evaluations brings challenges to the analysis of clinical trials due to missing data. Although several endpoints may be affected, progression-free survival (PFS) is of major concern, given its frequent use as primary endpoint in advanced cancer and the fact that missed radiographic assessments are to be expected. If patients with progression have delayed radiographic assessment due to the pandemic, there is controversy between censoring at the last visit prior to a shutdown period or ascribing the progression date to the day the assessment is eventually done after the end of the shutdown. The recent introduction of the estimand framework creates an opportunity to define more precisely the target of estimation and ensure alignment between the scientific question and the statistical analysis. Two basic approaches can be considered for handling missing tumor scans due to the pandemic: a “treatment policy” strategy, which consists in ascribing events to the time they are observed, and a “hypothetical” approach of censoring patients with events during the shutdown period at the last assessment prior to that period. In this article, we show through simulations how these two approaches may affect the overall power of a study and bias the estimated treatment effect and median PFS estimates. As a general rule, we suggest that the treatment policy approach, which conforms with the intent-to-treat principle, should be the primary analysis in order to avoid unnecessary loss of power and minimize bias in median PFS estimates.

Collection Guidelines to Achieve a Viable Caper Commercial Propagation

The caper (Capparis spinosa L.) is a perennial plant characteristic of the Mediterranean region that presents difficulties in its propagation, both vegetatively and by seeds. The main aim of this study is to provide collection guidelines to achieve a viable caper commercial propagation, for which three experiments were undertaken to determine the viability and germination in different seed lots. In the first experiment, commercial and own produced seeds (collected with the same criteria as commercial seeds) were analysed; the commercial seeds presented the lowest viability and germination. The second experiment analysed the effect of the fruit (from which the seeds were extracted) at its maturation stage, obtaining the lowest seed viability and germination in the seeds extracted from the dry fruits. In the third experiment, seed viability and germination were analysed immediately after collection, following a short drying period (3 d), and after six storage months. Viability and germination decreased with seed storage. Overall, it can be stated that caper seeds are sensitive to desiccation; consequently, a general rule of thumb is to collect the fruits once a week, to extract the seeds, and to plant them immediately for germination.