ctla4 blockade
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2021 ◽  
Author(s):  
Marco A. De Velasco ◽  
Yurie Kura ◽  
Noriko Sako ◽  
Naomi Ando ◽  
Kazuko Sakai ◽  
...  

2021 ◽  
Vol 14 (3) ◽  
pp. 101014
Author(s):  
Arjun Khunger ◽  
Ghanashyam Sarikonda ◽  
Jennifer Tsau ◽  
Anil Pahuja ◽  
Zeni Alfonso ◽  
...  

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 528 ◽  
Author(s):  
Yasuhiro Maruoka ◽  
Aki Furusawa ◽  
Ryuhei Okada ◽  
Fuyuki Inagaki ◽  
Daiki Fujimura ◽  
...  

Near infrared photoimmunotherapy (NIR-PIT) is a newly developed and highly selective cancer treatment that induces necrotic/immunogenic cell death. It employs a monoclonal antibody (mAb) conjugated to a photo-absorber dye, IRDye700DX, which is activated by NIR light. Tumor-targeting NIR-PIT is also at least partly mediated by a profound immune response against the tumor. Cytotoxic T-lymphocyte antigen-4 (CTLA4) is widely recognized as a major immune checkpoint protein, which inhibits the immune response against tumors and is therefore, a target for systemic blockade. We investigated the effect of combining tumor-targeted NIR-PIT against the cell-surface antigen, CD44, which is known as a cancer stem cell marker, with a systemic CTLA4 immune checkpoint inhibitor in three syngeneic tumor models (MC38-luc, LL/2, and MOC1). CD44-targeted NIR-PIT combined with CTLA4 blockade showed greater tumor growth inhibition with longer survival compared with CTLA4 blockade alone in all tumor models. NIR-PIT and CTLA4 blockade produced more complete remission in MOC1 tumors (44%) than NIR-PIT and programmed cell death protein 1 (PD-1) blockade (8%), which was reported in our previous paper. However, the combination of NIR-PIT and CTLA4 blockade was less effective in MC38-luc tumors (11%) than the combination of NIR-PIT and PD-1 blockade (70%). Nonetheless, in many cases ineffective results with NIR-PIT and PD-1 blockade were reversed with NIR-PIT and CTLA4 blockade.


2019 ◽  
Vol 146 (6) ◽  
pp. 1730-1740 ◽  
Author(s):  
Xichen Zheng ◽  
Naidong Zhang ◽  
Long Qian ◽  
Xuexiang Wang ◽  
Peng Fan ◽  
...  

immuneACCESS ◽  
2018 ◽  
Author(s):  
L Robert ◽  
J Tsoi ◽  
X Wang ◽  
R Emerson ◽  
B Homet ◽  
...  

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Janet Retseck ◽  
Alexis Nasr ◽  
Yan Lin ◽  
Huang Lin ◽  
Prateek Mendiratta ◽  
...  

2018 ◽  
Vol 16 (1) ◽  
Author(s):  
Sara Valpione ◽  
Sandro Pasquali ◽  
Luca Giovanni Campana ◽  
Luisa Piccin ◽  
Simone Mocellin ◽  
...  

2018 ◽  
Vol 7 (6) ◽  
pp. e1431088 ◽  
Author(s):  
Elizabeth Ahern ◽  
Heidi Harjunpää ◽  
Jake S. O'Donnell ◽  
Stacey Allen ◽  
William C. Dougall ◽  
...  

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