The analysis of physical principles, which can be successfully uses for development a new generation of orientation and navigation systems, as well as errors limiting the prospects for improving these systems, is presented. Monitoring and control of motion in near-Earth space by the gravitational potential, by the geomagnetic field, on the base of the atomic interferometer, by the global pulsar navigation grid and using other methods are considered. New methods based on the results of research in the field of observational astrophysical, laser and atomic interferometry, and the optics of moving media are considered.