Influence of the level of arsenic (As) exposure and the presence of T860C polymorphism in human As urinary metabolic profile

The influence, on arsenic (As) urinary metabolic profile, of the level of As exposure was evaluated on chronic-exposed inhabitants of several locations of the Chaco-Pampean Plains in Argentina. Urinary As (UAs) was quantified as a measure of the level of exposure. The metabolic profile of UAs (inorganic As, monomethylarsonic acid, and dimethylarsinic acid) was also evaluated. The presence of T860C polymorphism on the arsenite methyltransferase encoding gene was investigated by desquamation of buccal cells. UAs showed a wide range of levels (from 18 µg/g to 4103 µg/g) of creatinine. A clear influence of age, gender, level of As exposure, and the presence of T860C polymorphism was observed on As metabolic profile. The influence of the level of exposure showed to be different between individuals carrying the wild type (WT) and the heterozygous (H) genotypes. Metabolic profile of individuals carrying the WT genotype seemed to be influenced by the level of exposure, while individuals with the H genotype did not. It is concluded that the level of As exposure seemed to have a significant influence on urinary metabolic profile of individuals carrying the WT genotype. In contrast, individuals carrying the H genotype seemed not to be affected the same way by increasing the As exposure level.

Geochemical characterization, correlation, and optical dating of tephra in alluvial sequences of central western Argentina

The synthesis of paleoclimatic archives provided by loess and alluvial sequences of central Argentina has been hindered by the lack of a cohesive lithostratigraphic framework extending across the Chaco–Pampean plains and catchments of the Rios Desaguadero, Colorado, and Negro. This condition originates in part from the dearth of absolute chronological controls. The occurrence of discrete tephra layers across this region may provide an opportunity to address this deficiency if a tephrochronological framework can be established. The potential of such a project is assessed within the context of a pilot study constrained within alluvial sequences of central western Argentina proximal to potential source vents in the Southern Volcanic Zone. The intersite discrimination and correlation of tephra layers on a geochemical basis is examined, with indirect chronological control for the eruption of each generated by optical dating. Alluvial sediments on either side of each of five tephra units at a type site were dated using the optically stimulated luminescence of fine-silt-sized quartz, thus providing an age control on each tephra (ca. 24,000, 30,000, 32,000, 39,000, and 48,000 yr). The geochemical composition of each tephra was derived. Using these data, tephra layers at other sites in the study area were geochemically analyzed and in instances of statistical concordance in major oxide structure, correlated to the type site and therefore ascribed ages. This methodology identified a further sixth volcanic event between ca. 24,000 and 30,000 yr not registered by type-site tephras. The extension of this initial tephrochronological framework beyond the alluvial sequences of central western Argentina is encouraged by the occurrence of geochemically distinct tephra verified and dated in this study.