Double-edge sword roles of iron in driving energy production versus instigating ferroptosis

Iron is vital for many physiological functions, including energy production, and dysregulated iron homeostasis underlies a number of pathologies. Ferroptosis is a recently recognized form of regulated cell death that is characterized by iron dependency and lipid peroxidation, and this process has been reported to be involved in multiple diseases. The mechanisms underlying ferroptosis are complex, and involve both well-described pathways (including the iron-induced Fenton reaction, impaired antioxidant capacity, and mitochondrial dysfunction) and novel interactions linked to cellular energy production. In this review, we examine the contribution of iron to diverse metabolic activities and their relationship to ferroptosis. There is an emphasis on the role of iron in driving energy production and its link to ferroptosis under both physiological and pathological conditions. In conclusion, excess reactive oxygen species production driven by disordered iron metabolism, which induces Fenton reaction and/or impairs mitochondrial function and energy metabolism, is a key inducer of ferroptosis.

Photothermal Therapy may be a Double-edge Sword by Inducing the Formation of Bacterial Antibiotic Tolerance

Photothermal nanoparticles are thought to be the most potential candidates against infectious disease, by disrupting cell membrane and inhibiting metabolism. However, subpopulation survived with this low-activity state may be endowed...

Mode I stress intensity factor with various crack types

Presence of cracks in mechanical components needs much attention, where the stress field is affected by cracks and the propagation of cracks may be occurred causing the damage. The objective of this paper is to present an investigation of crack type effect on crack severity in a finite plate. Three cases of cracked plate with three different types of cracks are assumed in this work, i.e., single edge crack, center crack and double edge crack. 2D numerical models of cases of cracked plate are established in finite element analysis (FEA), ANSYS software by adopting PLANE 183 element. Values of FEA mode I stress intensity factor SIF and Von-Mises stress at crack apex are determined for cases of cracked plate under tensile stress with different values. To identify the crack severity, the comparison of FEA results for different cracked cases is made. The comparison showed that, single edge cracked plate (SECP) has the maximum values of mode I SIF and Von-Mises stress at crack apex, i.e. the greatest crack severity is considered. Also, values of FEA Von-Mises stress at crack apex for center cracked plate (CCP) are moderate and for double edge cracked plate (DECP) are the minimum. Besides, in case of high crack lengths, it is found that, FEA results of mode I SIF in case of (CCP) are higher than those of in case of (DECP). Consequently, crack severity is considered as moderate in case of (CCP) and the minimum in case of (DECP). Empirical formulas are used to approximately estimate mode I SIF for all the case studies of cracked plate in this study and the results are compared to those of FEA. A good agreement between analytical and FEA results has been showed by this comparison.