Hydrodynamic couplings of colloidal ellipsoids diffusing in channels

The hydrodynamic interactions (HIs) of two colloidal spheres characterized by the translation–translation (T–T) couplings have been studied under various confinements, but little is known regarding the HIs of anisotropic particles and rotational motions, which are common in nature and industry. Here, we study the T–T, rotation–rotation (R–R) and translation–rotation (T–R) hydrodynamic couplings of two colloidal ellipsoids sediment on the bottoms of channels in experiment, theory and simulation. We find that the degree of confinement and the particle shape anisotropy are critical tuning factors resulting in anomalous hydrodynamic and diffusive behaviours. The negative R–R coupling reflects the tendency of opposite rotations of two neighbouring ellipsoids. The positive T–R coupling reflects that an ellipsoid rotates away from the channel axis as another ellipsoid approaches. As the channel width increases, the positive T–T coupling changes to an abnormal negative coupling, indicating that the single-file diffusion can exist even in wide channels. By contrast, only positive T–T couplings were observed for spheres in channels. The T–T coupling increases with the aspect ratio p. The R–R coupling is the maximum at a moderate p ~ 2.8. The T–R coupling is the maximum at a moderate degree of confinement. The spatial range of HIs is longer than that of spheres and increases with p. We propose a simple model which reproduces some coupling phenomena between two ellipsoids, and it is further confirmed by low-Reynolds-number hydrodynamic simulation. These findings shed new light on anisotropic particle diffusion in porous media, transport through membranes, microfluidics and microrheology.

Modelling of filamentous phage-induced antibiotic tolerance of P.aeruginosa

Filamentous molecules tend to spontaneously assemble into liquid crystalline droplets with a tactoid morphology in the environments with the high concentration on non-adsorbing molecules. Tactoids of filamentous Pf bacteriophage, such as those produced by Pseudomonas aeruginosa, have been linked with increased antibiotic tolerance. We modelled this system and show that tactoids, composed of filamentous Pf virions, can lead to antibiotic tolerance by acting as an adsorptive diffusion barrier. The continuum model, reminiscent of descriptions of reactive diffusion in porous media, has been solved numerically and good agreement was found with the analytical results, obtained using a homogenisation approach. We find that the formation of tactoids significantly increases antibiotic diffusion times leading to stronger antibiotic resistance.

Addressing nonlinear transient diffusion in porous media through transformations

The nonlinear differential equation describing flow of a constant compressibility liquid in a porous medium is examined in terms of the Kirchhoff and Cole-Hopf transformations. A quantitative measure of the applicability of representing flow by a slightly compressible liquid – which leads to a linear differential equation, the Theis equation – is identified. The classical Theis problem and the finite-well-radius problem in a system that is infinite in its areal extent are used as prototypes to address concepts discussed. This choice is dictated by the ubiquity of solutions that depend on these archetypal examples for examining transient diffusion. Notwithstanding that the Kirchhoff and Cole-Hopf transformations arrive at a linear differential equation, for the specific purposes of this work – the estimation of the hydraulic properties of rocks, the Kirchhoff transformation is much more advantageous in a number of ways; these are documented. Insights into the structure of the nonlinear solution are provided. The results of this work should prove useful in many contexts of mathematical physics though developed in the framework of applications pertaining to the earth sciences.