The in-depth analysis of the strategies for the coordinated and continuous development of population, resources, environment, economy, and society based on the engineering management model is highly important for the sustainable development of the regional economy and society. In this article, a population-economy-resources-environment bilevel optimization model is established based on the economic and social development in a provincial region. The method of bilevel optimization is adopted to introduce the specific bilevel optimization model. The concept and objectives of the bilevel optimization are explained, and its corresponding technical applications are described. In this article, the development in coordinated economic and social development of population, resources, and environment is analyzed and compared based on the bilevel optimization model. In particular, the evolution and changes before and after the implementation of engineering management are studied. Through the results, it can be observed that after the implementation of project management, the coefficient of industry location has presented a downward trend, and the coordinated development of population, resources, environment, economy, and society has become more coordinated.