mPalliative Care Link: Examination of a Mobile Solution to Palliative Care Coordination Among Tanzanian Patients With Cancer

PURPOSE Late-stage cancer patient symptom control is a national priority in Tanzania. Mobile health promises to improve the reach of a limited pool of palliative care specialists through interprofessional, community-based care coordination. This work assessed the effectiveness of a smartphone- or Web-based app, mPalliative Care Link (mPCL), to extend specialist access via shared data and communication with local health workers. Central to mPCL is the African Palliative care Outcome Scale (POS), adapted for automated mobile symptom assessment and response. METHODS Adult patients with incurable cancer were randomly assigned at hospital discharge to mPCL versus phone-contact POS collection. Sociodemographic, clinical, and POS data were obtained at baseline. Twice-weekly POS responses were collected and managed via mPCL or phone contact with clinician study personnel for up to 4 months, on the basis of study arm assignment. Patient end-of-study care satisfaction was assessed via phone survey. RESULTS Forty-nine patients per arm participated. Comparison of baseline characteristics showed an insignificant trend toward more women ( P = .07) and higher discharge morphine use ( P = .09) in the mPCL group compared with phone-contact and significant between-group differences in cancer types ( P = .003). Proportions of deaths were near equal between groups (mPCL: 27%; phone-contact: 29%). Overall symptom severity was significantly lower in the phone-contact group ( P < .0001), and symptom severity decreased over time in both groups ( P = .0001); however, between-group change in overall symptoms over time did not vary significantly ( P = .34). Care satisfaction was generally high in both groups. CONCLUSION Higher symptom severity scores in the mPCL arm likely reflect between-group sociodemographic and clinical differences and clinical support of phone-contact arm participants. Similar rates of care satisfaction in both groups suggest that mPCL may support symptom-focused care coordination in a more efficient and scalable manner than phone contact. A broader study of mPCL's cost efficiency and utility in Tanzania is needed.

NOMOPHOBIA: A META-ANALYTIC REVIEW

Nomophobia is No mobile phone phobia. It is described as the dread of being besides a bendy device or past adaptable cell phone contact. Nomophobia is on the ascent over the globe. Here the inspector prepared to journey the contemplates directed in India simply as outside to have a good sized comprehension on the thinking of nomophobia, its estimations, system of consider, associated ideas, proposals etc. The professionals used meta-examination as the system for shifting closer the issue. Ten ponders which met the idea measures had been picked for this consider. Revelations of the reflect on consideration on offers the thinking that nomophobia is primary among all age packs, the majority of the contemplates directed in school understudies. Nomo phobic humans have physical, social and mental issues. Mental troubles consolidates stretch, disquiet, wretchedness, bitterness and so forth Causal elements of nomophobia is ordinary round the planet. KEYWORDS: Nomophobia

mPalliative Care Link: Examination of a mobile solution to palliative care coordination among Tanzanian cancer patients.

1584 Background: Cancer is a growing public health concern in Tanzania (and throughout sub-Saharan Africa), with a majority of cases presenting in late stage with associated distress, ie, pain. Access to specialty palliative care (PC) is a national priority in Tanzania; however, there are limited numbers of PC specialists (hereafter, specialists). Mobile health promises to extend the reach of a limited pool of specialists through inter-professional, community-based care coordination. This work assessed the effectiveness of a smartphone-/web-based application, mobile Palliative Care Link (mPCL), to extend specialist access via shared data and communication with local health workers (LHWs). Central to mPCL is the African Palliative care Outcome Scale (POS), adapted for automated, scheduled mobile symptom assessment and response. Methods: Following consent, incurable adult cancer patients were randomized at hospital discharge from a large urban, government-supported Tanzanian cancer institute to one of two study arms—mPCL or phone-contact POS collection. Baseline sociodemographic, clinical and POS data were recorded. Twice-weekly POS responses were collected and managed via mPCL or by phone-contact with clinician study personnel for up to 4-months depending on respective study arm. Patient end-of-study care satisfaction was assessed via phone-survey. Results: Forty-nine patients per arm participated. Comparison of baseline characteristics showed a trend toward more women ( p= 0.07) and higher discharge morphine use ( p= 0.09) in the mPCL versus phone-contact groups, respectively, and significant between-group differences in cancer types ( p= 0.003). Proportion of deaths were near-equal comparing groups [26% ( n= 13) mPCL versus 28% ( n= 14) phone-contact]. Overall symptom severity was lower in the phone-contact group ( p <0.0001) and symptom severity decreased over time in both groups ( p= 0.0001); however, between-group change in overall symptoms over time did not vary ( p= 0.34). Care satisfaction was high overall in both groups with few between-groups differences, ie, greater provider response to questions and concerns in the phone-contact arm and greater provision of spiritual support in the mPCL arm. Conclusions: Higher symptom severity scores in the mPCL arm likely reflecting between-group sociodemographic/clinical differences and clinical support of phone-contact arm participants. Similar rates of care satisfaction in both groups suggest that, compared to phone-based support, mPCL may facilitate effective symptom-focused care in a more efficient and scalable manner. Study limitations include a small sample of patients from a single urban hospital and lack of a true usual care arm. Broader study of mPCL’s cost-efficiency and utility in Tanzania is needed. This work promises to close a large PC gap in under-resourced settings throughout Tanzania and other LMICs.

Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining

We study the effects of two mechanisms which increase the efficacy of contact-tracing applications (CTAs) such as the mobile phone contact-tracing applications that have been used during the COVID-19 epidemic. The first mechanism is the introduction of user referrals. We compare four scenarios for the uptake of CTAs—(1) the p% of individuals that use the CTA are chosen randomly, (2) a smaller initial set of randomly-chosen users each refer a contact to use the CTA, achieving p% in total, (3) a small initial set of randomly-chosen users each refer around half of their contacts to use the CTA, achieving p% in total, and (4) for comparison, an idealised scenario in which the p% of the population that uses the CTA is the p% with the most contacts. Using agent-based epidemiological models incorporating a geometric space, we find that, even when the uptake percentage p% is small, CTAs are an effective tool for mitigating the spread of the epidemic in all scenarios. Moreover, user referrals significantly improve efficacy. In addition, it turns out that user referrals reduce the quarantine load. The second mechanism for increasing the efficacy of CTAs is tuning the severity of quarantine measures. Our modelling shows that using CTAs with mild quarantine measures is effective in reducing the maximum hospital load and the number of people who become ill, but leads to a relatively high quarantine load, which may cause economic disruption. Fortunately, under stricter quarantine measures, the advantages are maintained but the quarantine load is reduced. Our models incorporate geometric inhomogeneous random graphs to study the effects of the presence of super-spreaders and of the absence of long-distant contacts (e.g., through travel restrictions) on our conclusions.

Bridging the Telemedicine Gap Among Seniors During the COVID-19 Pandemic

At the onset of the COVID-19 pandemic, many senior patients in the USC-Keck Family Medicine clinics were limited or lacking in telemedicine participation. Three factors contributed: lack of video-enabled devices, technological literacy, and/or absence of Wi-Fi connectivity. We addressed the first 2 of these factors. Via phone contact, 9 patients agreed to receive donated Android or Apple devices and to trial instruction manuals for use. Donated equipment and instructions were prepared and delivered in accordance with pandemic guidelines. Follow-up calls indicated that 4 participants were able to set up their devices and 3 of whom had connected with their providers. The remaining 5 participants had not set up their devices by the end of the follow-up period, had difficulty with device setup, accessing applications necessary for telemedicine, or had limited access to Wi-Fi. This project highlights some telemedicine barriers that senior patients may overcome with the additional support of care providers.

Increasing efficacy of contact-tracing applications by user referrals and stricter quarantining

We study the effects of two mechanisms which increase the efficacy of contact-tracing applications (CTAs) such as the mobile phone contact-tracing applications that have been used during the COVID-19 epidemic. The first mechanism is the introduction of user referrals. We compare four scenarios for the uptake of CTAs — (1) the p% of individuals that use the CTA are chosen randomly, (2) a smaller initial set of randomly-chosen users each refer a contact to use the CTA, achieving p% in total, (3) a small initial set of randomly-chosen users each refer around half of their contacts to use the CTA, achieving p% in total, and (4) for comparison, an idealised scenario in which the p% of the population that uses the CTA is the p% with the most contacts. Using agent-based epidemiological models incorporating a geometric space, we find that, even when the uptake percentage p% is small, CTAs are an effective tool for mitigating the spread of the epidemic in all scenarios. Moreover, user referrals significantly improve efficacy. In addition, it turns out that user referrals reduce the yearly quarantine load. The second mechanism for increasing the efficacy of CTAs is tuning the severity of quarantine measures. Our modelling shows that using CTAs with mild quarantine measures is effective in reducing the maximum hospital load and the number of people who become ill, but leads to a relatively high quarantine load, which may cause economic disruption. Fortunately, under stricter quarantine measures, the advantages are maintained but the quarantine load is reduced. Our models incorporate geometric inhomogeneous random graphs to study the effects of the presence of super-spreaders and of the absence of long-distant contacts (e.g., through travel restrictions) on our conclusions.

Effects on congestion, natriuretic peptides, diuretic efficiency, and renal function during different dose and administration of intravenous loop diuretic: preliminary data of DIUR-AHF Trial

Background Although loop diuretic is the cornerstone of treatment in acute heart failure (AHF) there is no consensus about the best modality and amount to be used during acute phase. Current Guidelines do not provide specific insights regarding timing course and target dose. Usually physicians double the oral domestic amount when they start intravenous infusion, but a precise algorithm does not exist. Aims To compare admission and pre discharge clinical congestion and BNP trend in relation to furosemide amount and modality administration; 2- to evaluate diuretic efficiency and renal function in the four arms and the potential effects on outcome. Methods This is a multicentre prospective Trial (DIUR-AHF) designed in order to clarify the correct loop diuretic target avoiding potential side effects. The study enrolled patients with AHF BNP level &gt;100 pg/ml and congestion signs. Patients were divided in four arms in accordance with modality administration: Continuous (Ci) vs Bolus (Bi) and dose administered Low (LD) vs High (HD) considering a cutoff 125 mg/die. All patients executed a clinical congestion evaluation and Chest radiography at admission and pre discharge, BNP sample and renal function were measured during the first 12 hours and before discharge. Diuretic efficiency (DE) defined as weight change per 40 mg of furosemide during infusional period. DE was estimated as the net fluid output produced per 40 mg of furosemide equivalents, Follow up were obtained by direct visit or phone contact at 30 and 60 days after discharge Results We included 268 hospitalized patients with a mean BNP level 987±440 pg /ml, mean congestion score (3.5±2) creatinine and GFR value were 1.6±0.7 mg/dl; and 48±20 ml/min/m2 respectively. At admission BNP and Creatinine were modestly increased in HD (P&lt;0.01) compared with all other groups. Pre discharge Congestion score were increased in Bi and HD groups (2.5±1 vs 1±1), similarly BNP levels were increased in Bi and HD with respect to Ci and LD (454±215 and 413±223 vs 288±170 and 312±248 p&lt;0.05). Whereas DE were significantly increased in Ci compared with the other arms (−1.23 vs −0.55 p&lt;0.01). In all groups, low DE, residual congestion and BNP reduction &lt;30% resulted in escalation of diuretic strategies and impaired outcome (HR 1.88 [1.16–204]; 2.1 [1.4–2.8]; 1.3 [0.88–2.1]). A significant correlation between poor DE and residual congestion was recruited (r=0.76). Worsening Renal function (WRF) occurred much more in HD and Ci compared to LD and Bi (HD 44%, Ci 35% vs LD 33% and Bi 23% p&lt;0.01) without significant effects on outcome. Conclusions HD and Bi of furosemide are both related with reduced congestion and invreased BNP level before discharge. In all groups low DE residual congestion and poor BNP reduction appear associated with higher rate of adverse events. Current data provide additional features for AHF patients during intravenous loop diuretic administration Funding Acknowledgement Type of funding source: None

Contact Between Non-Resident Parents and Their Children During the COVID-19 in Hungary

Several studies have examined the factors that can influence contact between non-resident parents and their children (Goldberg & Carlson 2015, Skevik 2006). The distance between the place of residence of the non-resident parent and their child(ren) has been found to be important in terms of the frequency of in-person contact (Manning et al. 2003; Cheadle et al. 2010). The majority of research on this topic focuses on the frequency and quality of face-to-face visitation between non-resident parents and their children (Kalmijn, 2015, Köppen et al., Szalma & Rékai 2019). Although some studies have explored other types of contact such as overnight stays (Haux & Platt, 2020; King et al. 2004) and phone contact (Leite & McKenry, 2002; Meggiolaro & Ongaro, 2014), these remain marginal. Other types of communications between non-resident parents and their children might be under-researched because face-to-face contact is a condition for other types of contact (Schier 2016).