Mesoporous ZnO nanocapsules for the induction of enhanced antigen-specific immunological responses

Herein, we have designed novel mesoporous ZnO (mZnO) nanocapsules with a size of ∼12 nm and loaded them with Ova protein. In vivo studies in mice highlight the potency of the antigen loaded mZnO nanocapsules as an efficient adjuvant and vaccine delivery vehicle.

The potential of porous silicon particles for multi-epitopic vaccine development

Vaccination is a crucial approach to eradicate and control amyriad of infectious and non-communicable diseases. Subunit vaccines are considered the most convenient approach for vaccine formulation; however, the development of new adjuvants and vaccine delivery vehicles to improve the immunogenicity of such formulations is needed. The authors of this review describe the recent application of porous silicon particles (PSiP) as both a potential vaccine delivery vehicle and adjuvant. PSiP are attractive for this application due to its safety, biodegradability and compatibility for functionalization. Herein, the development of multi-epitope cancer vaccines is discussed as an example on how PSiP are promising materials for the development of innovative vaccines.