Complex regional pain syndrome in a patient with neuroendocrine tumour under treatment with everolimus

Everolimus is an immunosuppressant agent used in organ transplantation and, more recently, in cancer therapy. It has demonstrated beneficial effects in breast cancer, renal cancer, and neuroendocrine tumours. However, the treatment is not without side effects, some of which are still little known. We report the case of a 56 year-old man with a diagnosis of neuroendocrine tumour who developed a complex regional pain syndrome (CRPS) secondary to treatment with everolimus. CRPS has been linked to treatments with everolimus in renal and breast cancer patients as well as in renal transplant patients. To our knowledge, this is the first case of CRPS in a neuroendocrine tumour patient on everolimus treatment.

Recurrent bilateral frontal lobe lesion with maladaptive schema modes and PTSD symptoms: a case study

The frontal lobe is responsible for high-order functioning, such as memory, attention, decision-making, and personality. Lesions in the frontal lobe may lead to different physical and psychological problems. The current study was conducted to examine the emotional, cognitive, and behavioural states and coping strategies of a patient with recurrent bilateral frontal lobe lesion. It also attempted to determine post-traumatic stress disorder (PTSD) symptoms in a patient. This study described the case of an adult with recurrent bilateral frontal lobe tumour. It covered the clinical presentation, administration of Urdu translation of the Schema Mode Inventory (SMI) and Clinician-Administered PTSD Scale for DSM-5 (CAPS-5), and analysis of the case. The results of the study showed that the recurrent bilateral frontal lobe brain tumour patient engaged in child mode and had a dysfunctional coping style and a maladaptive punitive parent mode. Furthermore, the patient also had moderate PTSD symptoms. Continuous....

D-DIMER AND FIBRINOGEN IN PATIENTS UNDERWENT SURGERY IN MALIGNANT AND BENIGN OVARIAN TUMOR (D-Dimer Dan Fibrinogen Pada Pasien-Pasien Yang Menjalani Tindakan Pembedahan Pada Tumor Ovarium Ganas Dan Jinak)

Ovarian tumour ranks second in gynecology tumour cases and ranks second in gynecology tumour death in Indonesia. Tumour cause hypercoagulable that increase risk of thrombosis by procoagulant mechanism. Tumout cells also can cause hyperfibrinogenemmia that can cause bleeding. The aim of study was to know D-dimer and fibrinogen value to investigate primary hyperfibrinolysis on malignant and benign ovarian tumour; and to know whether operation procedure on malignant and benign tumour change D-dimer and fibrinogen value. Prospective analysis study, subject were malignant and benign ovarian tumour patients undergoing surgery in Haji Adam Malik Hospital, Medan. One way Annova test dan Wilcoxon Sum-Rank test were performed. Stastical differentiation is indicate with p<0,05. Study subject was 16 patient where 8 malignant and benign ovarian tumour patient respectively. Malignant ovarian tumour D-dimer values was higher than benign ovarian tumour (p<0,01) that indicate fibrinolysis increase in malignant ovarian tumour. Malignant ovarian tumour fibrinogen values as same as benign ovarian tumour (p>0,05) that indicate the fibrinolysis in ovarian tumour wasn’t primary hyperfibrinolysis. Surgery procedure didn’t influence D-dimer and fibrinogen values. Primary hyperfibrinolysis wasn’t occur in ovarian tumour.Keywords : Ovarian tumour, malignant, benign, D-dimer, fibrinogen.

PS02.136: SURGICAL INTERVENTION FOR RECURRENT CANCER OF THE ESOPHAGUS

Background CASE REPORT ON SUCCESFUL SURGICAL INTERVENTION FOR RECURRENT CA OESOPHAGUS 45 year old female diagnosed with cancer of the oesophagus in 2013, CT Scan showed operable tumour. Patient underwent Ivor Lewis oesophagectomy. Histopatholgy showed pT2N0Mx(Stage IIA). Patient was followed up and was noted to be loosing weight in April 2016, upper GI Endoscopy showed recurrence of the tumour, at the intrathoracic stomach level.CT Scan revealed a tumour involving the stomach but no pulmonary nodules. In Multidisciplinary discussion it was agreed to offer patient surgical resection. At surgery the intrathoracic stomach was mobilised and resection done. Formal laparotomy was performed and the transverse colon prepared for colonic interposition at the cervical region. At the time of surgery the patient's weight was 38 kg, this increased to 45kg within the first 6 months after surgery. Patient underwent adjuvant chemotherapy and is doing well 2 years after the second surgery. Methods this is a case report. Results case report. Conclusion recurrence after esophagectomy is high and some patients can benefit from redo surgery. Disclosure All authors have declared no conflicts of interest.