A Data-Driven Memory-Dependent Modeling Framework for Anomalous Rheology: Application to Urinary Bladder Tissue

We introduce a data-driven fractional modeling framework for complex materials, and particularly bio-tissues. From multi-step relaxation experiments of distinct anatomical locations of porcine urinary bladder, we identify an anomalous relaxation character, with two power-law-like behaviors for short/long long times, and nonlinearity for strains greater than 25%. The first component of our framework is an existence study, to determine admissible fractional viscoelastic models that qualitatively describe linear relaxation. After the linear viscoelastic model is selected, the second stage adds large-strain effects to the framework through a fractional quasi-linear viscoelastic approach for the nonlinear elastic response of the bio-tissue of interest. From single-step relaxation data of the urinary bladder, a fractional Maxwell model captures both short/long-term behaviors with two fractional orders, being the most suitable model for small strains at the first stage. For the second stage, multi-step relaxation data under large strains were employed to calibrate a four-parameter fractional quasi-linear viscoelastic model, that combines a Scott-Blair relaxation function and an exponential instantaneous stress response, to describe the elastin/collagen phases of bladder rheology. Our obtained results demonstrate that the employed fractional quasi-linear model, with a single fractional order in the range α = 0.25–0.30, is suitable for the porcine urinary bladder, producing errors below 2% without need for recalibration over subsequent applied strains. We conclude that fractional models are attractive tools to capture the bladder tissue behavior under small-to-large strains and multiple time scales, therefore being potential alternatives to describe multiple stages of bladder functionality.

Lagrange multiplier approach to unilateral indentation problems: Well-posedness and application to linearized viscoelasticity with non-invertible constitutive response

The Boussinesq problem describing indentation of a rigid punch of arbitrary shape into a deformable solid body is studied within the context of a linear viscoelastic model. Due to the presence of a non-local integral constraint prescribing the total contact force, the unilateral indentation problem is formulated in the general form as a quasi-variational inequality with unknown indentation depth, and the Lagrange multiplier approach is applied to establish its well-posedness. The linear viscoelastic model that is considered assumes that the linearized strain is expressed by a material response function of the stress involving a Volterra convolution operator, thus the constitutive relation is not invertible. Since viscoelastic indentation problems may not be solvable in general, under the assumption of monotonically non-increasing contact area, the solution for linear viscoelasticity is constructed using the convolution for an increment of solutions from linearized elasticity. For the axisymmetric indentation of the viscoelastic half-space by a cone, based on the Papkovich–Neuber representation and Fourier–Bessel transform, a closed form analytical solution is constructed, which describes indentation testing within the holding-unloading phase.

Determination of an average quasi-linear viscoelastic model for the mechanical behavior of rat cervix

The objective of this study was to determine an average quasi-linear viscoelastic model for the mechanical behavior of rat cervix. The average model is applicable at defined displacement rates for virgin and pregnant tissues in the last trimester of pregnancy. After preconditioning, the displacement of 2 mm was applied to the distal halves of five pregnant rat’s cervices and 1 mm to the five virgin samples circumferentially. Uniaxial tension tests were employed at the displacement rates of 0.01, 0.1 and 1 mm/s randomly and were held for 10 min while the tissues were relaxed. Tensile and load-relaxation curves were well described by a quasi-linear viscoelastic model. Two average quasi-linear viscoelastic models were fitted to all 30 curves obtained from experiments for virgin and pregnant tissues. The average quasi-linear viscoelastic model coefficients were extracted using the average model equations. Cervical tissue is strongly viscoelastic. Determination of an average viscoelastic model of rat cervix may lead to a more precise description of the mechanical behavior of the virgin and pregnant tissues in the assessment of cervical insufficiency.