Clinical case study in acoustic-kinetic joint analysis: Synchronization and Evaluation of kinetic measurement data in AEA (Acoustic Emission Analysis) based diagnosis of arthritic knee joint defects

: In patients with arthritic knee joint defects the course of movement, the application of muscle forces and the degree of freedom of the joints of the lower limbs differs significantly from the corresponding data of a healthy proband. The enhanced acoustic-kinetic joint analysis based on AEA, ground force reaction measurements and video enhanced gait analysis permits the correlation of force data, joint angles and acoustic emission significant of defective joint cartilage regions. This diagnostic procedure permits a quantifiable and detailed non invasive diagnosis of lesion patterns in the arthritic knee joint by means of a synchronization algorithm. The AEA shows lesion signals in the first and third knee bend of the patient. The lesion signals are assigned to the joint angles and ground reaction force. Comparing the kinematical data there is a shift between the curves of the hip and the knee angle. Overall the force data represent an imbalance between the left and the right leg during the knee bends. The presentation of the three measurement systems, the method, the synchronization of the data sets and their final assessment as well as the occurring difficulties during a case of a clinical study are discussed. This would be helpful regarding further patients of the clinical study

Kinematic Alignment Technique for TKA on Degenerative Knees with Severe Bone Loss: A Report of 3 Cases

A severely degenerative knee joint with substantial bone attrition poses a significant challenge when performing Total Knee Arthroplasty (TKA) using the Kinematic Alignment (KA) technique. In order to restore the pre-arthritic knee anatomy, the surgeon has the task of estimating quantity and location of bone loss. We present three such cases and describe the key steps to safely perform KATKA in these complex situations.

Hong-Hui-Xiang Alleviates Pain Hypersensitivity in a Mouse Model of Monoarthritis

Background. Hong-Hui-Xiang (HHX) is a sterilized aqueous solution extracted from Illicium lanceolatum A.C. Smith widely used for pain relief in China. Despite its history, it is not well understood. In the present study, we used a mouse model of arthritic knee pain to investigate the antinociceptive effects of HHX and its potential side effects on weight and respiratory function, as well as on the liver, kidney, and heart. Methods. Mice were randomly assigned to four groups: saline and HHX at three doses (1 μl, 10 μl, and 50 μl). Each group was randomly divided to two subgroups: saline and CFA. After the first injection of HHX or saline on day 7, mechanical hyperalgesia was tested via the hind paw. Only after the tests had established that the analgesic effect had subsided was the next injection administered. A total of five injections were administered. Blood, knee joints, and other organs were collected for histopathological observation and biochemical detection. Objectives. We found that mechanical threshold of hind paw increased 2 h after of the initial injection HHX (10 μl and 50 μl), which lasted for at least 3 h. The analgesic effect lasted for three days after the second injection on day 8 and was approximately maintained for five days each time after the third injection. We also found a reduction in the diameter of the knee joint and suppression of synovial inflammation in response to treatment of HHX (10 μl and 50 μl). Meanwhile, HHX had no toxic effects on the liver, kidneys, and heart via histological and biochemical assays in all groups. Conclusion. HHX exerts antinociceptive and anti-inflammatory effects in a mouse model of arthritic knee pain. There were no obvious side effects on the liver, kidneys, or heart.