genome origins
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Genes ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 613 ◽  
Author(s):  
Ninel M. Vainshelbaum ◽  
Pawel Zayakin ◽  
Regina Kleina ◽  
Alessandro Giuliani ◽  
Jekaterina Erenpreisa

Triploidy in cancer is associated with poor prognosis, but its origins remain unclear. Here, we attempted to differentiate between random chromosomal and whole-genome origins of cancer triploidy. In silico meta-analysis was performed on 15 male malignant and five benign tumor cohorts (2928 karyotypes) extracted from the Mitelman Database, comparing their ploidy and combinations of sex chromosomes. A distinct near-triploid fraction was observed in all malignant tumor types, and was especially high in seminoma. For all tumor types, X-chromosome doubling, predominantly observed as XXY, correlated strongly with the near-triploid state (r ≈ 0.9, p < 0.001), negatively correlated with near-diploidy, and did not correlate with near-tetraploidy. A smaller near-triploid component with a doubled X-chromosome was also present in three of the five benign tumor types, especially notable in colon adenoma. Principal component analysis revealed a non-random correlation structure shaping the X-chromosome disomy distribution across all tumor types. We suggest that doubling of the maternal genome followed by pedogamic fusion with a paternal genome (a possible mimic of the fertilization aberration, 69, XXY digyny) associated with meiotic reprogramming may be responsible for the observed rearrangements of genome complements leading to cancer triploidy. The relatively frequent loss of the Y-chromosome results as a secondary factor from chromosome instability.



2019 ◽  
Vol 20 (7) ◽  
pp. 1774 ◽  
Author(s):  
Huan Zhu ◽  
Yuxin Hu ◽  
Feng Liu ◽  
Zhengyu Hu ◽  
Guoxiang Liu

Trentepohliales is an aerial order of Chlorophyta with approximately 80 species distributed mainly in tropical and subtropical regions. The taxonomy of this genus is quite difficult and presents a challenge for many phycologists. Although plentiful molecular data is available, most of the sequences are not identified at the species level. In the present study, we described a new specimen with detailed morphological data and identified it as Trentepohlia odorata. A phylogenetic analysis showed T. odorata as a novel lineage in Trentepohliales. T. odorata has the closest relationship with T. annulata, which is expected since sporangia of both species are without stalk cell and with dorsal pore. Species with such morphological characteristics may represent deep lineages in Trentepohliales. Although an increasing number of chloroplast genomes of Ulvophyceae have been reported in recent years, the whole plastome of Trentepohliales has not yet been reported. Thus, the chloroplast genome of Trentepohlia odorata was reported in the present study. The whole plastome was 399,372 bp in length, with 63 predicted protein-coding genes, 31 tRNAs, and 3 rRNAs. Additionally, we annotated 95 free-standing open reading frames, of which seven were annotated with plastid origins, 16 with eukaryotic genome origins, and 33 with bacterial genome origins. Four rpo genes (rpoA, rpoB, rpoC1, and rpoC2) were annotated within ORF clusters. These four genes were fragmented into several (partial) ORFs by in-frame stop codons. Additionally, we detected a frame shift mutation in the rpoB gene. The phylogenetic analysis supported that Trentepohliales clustered with Dasycladales and nested into the BDT clade (Bryopsidales, Dasycladales and Trentepohliales). Our results present the first whole chloroplast genome of a species of Trentepohliales and provided new data for understanding the evolution of the chloroplast genome in Ulvophyceae.



2016 ◽  
Vol 50 (4) ◽  
pp. 542-550 ◽  
Author(s):  
A. V. Zelenin ◽  
A. V. Rodionov ◽  
N. L. Bolsheva ◽  
E. D. Badaeva ◽  
O. V. Muravenko
Keyword(s):  


IMA Fungus ◽  
2015 ◽  
Vol 6 (1) ◽  
pp. 215-231 ◽  
Author(s):  
Hai D. T. Nguyen ◽  
Denise Chabot ◽  
Yuuri Hirooka ◽  
Robert W. Roberson ◽  
Keith A. Seifert
Keyword(s):  


2010 ◽  
Vol 289 (3-4) ◽  
pp. 165-179 ◽  
Author(s):  
Xincheng Zhou ◽  
Xinming Yang ◽  
Xiuquan Li ◽  
Lihui Li






2006 ◽  
Vol 24 (1) ◽  
pp. 217-227 ◽  
Author(s):  
B Kilian ◽  
H Özkan ◽  
O Deusch ◽  
S Effgen ◽  
A Brandolini ◽  
...  
Keyword(s):  


Genome ◽  
2004 ◽  
Vol 47 (2) ◽  
pp. 281-291 ◽  
Author(s):  
Mauro Bardini ◽  
David Lee ◽  
Paolo Donini ◽  
Anna Mariani ◽  
Silvia Gianì ◽  
...  

TBP (tubulin-based polymorphism) is a new molecular marker based tool that relies on the presence of intron-specific DNA polymorphisms of the plant β-tubulin gene family. The multifunctional and essential role of the tubulin proteins is reflected in the conservation of regions within their primary amino acid sequence. The ubiquitous nature of this gene family can be exploited using primers that amplify the first intron of different β-tubulin isotypes, revealing specific fingerprints. The method is rapid, simple, and reliable and does not require preliminary sequence information of the plant genome of interest. The ability of TBP to discriminate between accessions and species in oilseed rape, coffee, and lotus is shown. In all cases, TBP was able to detect specific genetic polymorphisms in the context of a simplified and readily appreciable pattern of DNA amplification. The application of TBP for assessing genetic diversity and genome origins in disseminated plant landraces rather than in highly inbred cultivated species is also discussed.Key words: β-tubulin, Brassica napus, Coffea, Lotus, SSRs.



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