Effect of Tramadol on Hormones and Lipid Peroxidation of male Rabbits

Tramadol manhandle straightforwardly impacts the discharge of luteinizing hormone and follicular stimulating g hormone from the front pituitary organ that diminishes the common discharge of luteinizing hormone in a pulsatile way, resulting in a negative impact on male testiclesdue to lower levels of testosterone hormone. Animals were orally given 40 mg/kg B.W. doses of tramadol. The tried measurements were given to rabbits each other day for 6 weeks. Tramadol significantly decreased body weight (BW), weight of brain, testes, testosterone, estradiol, follicle stimulating hormone (FSH), luteinizing hormone (LH), triiodothyronine (T3) and thyroxin hormone (T4). While, it caused significant increase in thiobarbituric acid-reactive substances (TBARS) concentrations in plasma, testes and brain. Keywords: Tramadol; Hormone; TBARS; Rabbits

Local Anesthetic Efficacy of Tramadol Hydrochloride with Adrenaline in the Extraction of Maxillary Teeth

Aims: To access the local anaesthetic effect of tramadol hydrochloride with adrenaline and its applicability in the extraction of maxillary teeth. Methodology: 100 patients were selected from the outpatient department (OPD) of oral and maxillofacial surgery, who needed extraction of any maxillary teeth and were under ASA – I category, and Using software SPSS Version 16 statistical analysis was done. Results: Tramadol hydrochloride 50mg with adrenaline 0.0225mg exhibits a local anaesthetic effect that enables successful and painless extraction of maxillary teeth. Conclusion: Tramadol hydrochloride does exhibit local anaesthetic effect and can be used as an alternative to conventional anaesthetics however due to certain unusual reasons this it cannot be proposed as a first-line agent. Keywords: Tramadol hydrochloride Local Anesthesia Extraction.