scholarly journals Olfactory reference plus Truman symptoms in one patient with Gilbert syndrome and antiphospholipid antibodies (Hughes disease) secondary to probable chronic Lyme neuroborreliosis

2022 ◽  
pp. 1-2
Author(s):  
João Almeida e Melo ◽  
João Gama Marques
Keyword(s):  
Affective Disorders ◽  
Antiphospholipid Antibodies ◽  
Lyme Neuroborreliosis ◽  
Affective Psychosis ◽  
Gilbert Syndrome ◽  
Rare Illnesses ◽  
Hughes Syndrome

Abstract After reading an article in the journal, regarding affective disorders in patients with rare illnesses, the authors would like to discuss a case of non-affective psychosis, presenting with olfactory reference and Truman symptoms, in a patient with three unusual conditions: Gilbert disease, Hughes syndrome and Lyme neuroborreliosis.

Depressed patients with schizophrenic or paranoid symptoms

1980 ◽  
Vol 10 (4) ◽  
pp. 665-675 ◽  
Author(s):  
I. F. Brockington ◽  
R. E. Kendell ◽  
S. Wainwright
Keyword(s):  
Family History ◽  
Affective Disorders ◽  
Final Diagnosis ◽  
Good Prognosis ◽  
Response To Treatment ◽  
Psychotic Symptoms ◽  
Affective Psychosis ◽  
Manic Depressive ◽  
Paranoid Symptoms ◽  
Definition Of

SYNOPSISFamily history, response to treatment and outcome are reported in a series of 76 patients presenting with both depression and schizophrenic or paranoid symptoms. About 10% of psychotic admissions to the Maudsley and Bethlem Royal Hospitals met a study definition of ‘schizodepressive’ illness. The patients were highly heterogeneous in history, clinical picture and outcome. Many followed a typical schizophrenic course, and others a typical course for affective disorders, but only 4 were given a final diagnosis of manic depressive disease. The best predictors of poor outcome were a mode of onset as an exacerbation of previous psychotic symptoms and the presence of schizophrenic symptoms at some time without depression. The best predictors of good outcome were Stephens' criteria of good prognosis schizophrenia and Kasanin's concept of ‘acute schizo-affective psychosis’. These findings are not easily reconciled with Kraepelin's two entities principle but suggest a continuum of outcome between schizophrenia and unipolar depressive psychosis.

Hughes syndrome and epilepsy: when to test for antiphospholipid antibodies?

Lupus ◽  
2016 ◽  
Vol 25 (13) ◽  
pp. 1397-1411 ◽  
Author(s):  
M H A Noureldine ◽  
G Harifi ◽  
A Berjawi ◽  
A A Haydar ◽  
M Nader ◽  
...  
Keyword(s):  
Antiphospholipid Antibodies ◽  
Hughes Syndrome

Organic Affective Psychosis Associated with the Routine Use of Non-prescription Cold Preparations

1990 ◽  
Vol 156 (4) ◽  
pp. 572-575 ◽  
Author(s):  
Terry M. Brown ◽  
Robert N. Golden ◽  
Dwight L. Evans
Keyword(s):  
Affective Disorder ◽  
Affective Disorders ◽  
Short Term ◽  
Drug Induced ◽  
Affective Psychosis ◽  
Clinical Reaction ◽  
Balance Hypothesis

A patient experienced an organic affective psychosis on three separate occasions after taking recommended doses of non-prescription cold/sinus preparations. The possible underlying pharmacological mechanisms of this clinical reaction lend support to the cholinergic-adrenergic balance hypothesis of affective disorders. Recognition of this acute drug-induced state can lead to appropriate short-term pharmacotherapy and can prevent misdiagnosis of a major affective disorder or schizophrenia.

Increased Risk of Affective Disorders in Males after Second Trimester Prenatal Exposure to the Dutch Hunger Winter of 1944–45

1995 ◽  
Vol 166 (5) ◽  
pp. 601-606 ◽  
Author(s):  
Alan S. Brown ◽  
Ezra S. Susser ◽  
Shang P. Lin ◽  
Richard Neugebauer ◽  
Jack M. Gorman
Keyword(s):  
Prenatal Exposure ◽  
Affective Disorders ◽  
Separate Analysis ◽  
Second Trimester ◽  
Birth Cohorts ◽  
Affective Psychosis ◽  
Affective Psychoses ◽  
Increased Risk ◽  
Famine Exposure ◽  
Prenatal Famine

BackgroundPrenatal and perinatal factors have been linked to affective disorders. We therefore undertook an exploratory study to determine whether prenatal exposure to severe famine was associated with an increased risk of affective disorders.MethodMonthly birth cohorts that were exposed and unexposed to the Dutch Hunger Winter of 1944–45 were identified. The cumulative incidences of affective psychoses and neurotic depression (ICD–9 criteria) were compared between exposed and unexposed cohorts during each trimester of gestation.ResultsThe relative risk (RR) of affective psychosis (broad and restricted definitions) among persons exposed to famine during the second trimester was significantly increased (broad: RR (95% confidence interval) = 1.62 (1.19, 2.20); restricted: 1.59 (1.14, 2.21)). Separate analysis by gender showed a significant association among males (broad: 2.26 (1.43, 3.57); restricted: 2.40 (1.49, 3.89)), but not females (broad: 1.28 (0.84, 1.94); restricted: 1.17 (0.73, 1.86)). The risk of neurotic depression was not increased after prenatal famine exposure.ConclusionsThese results suggest a possible relationship between prenatal famine during the second trimester and affective psychosis, lending plausibility to reports that have associated affective psychoses with prenatal exposures. Further studies of this relationship are warranted.

Modelling suicide risk in affective disorders

2001 ◽  
Vol 16 (7) ◽  
pp. 400-405 ◽  
Author(s):  
A.P. Boardman ◽  
D. Healy
Keyword(s):  
Affective Disorders ◽  
Psychiatric Morbidity ◽  
Secondary Analysis ◽  
Lifetime Prevalence ◽  
Primary Data ◽  
Community Based ◽  
Data Set ◽  
Affective Psychosis ◽  
Lifetime Prevalence Rate ◽  
Using Data

SummaryBackgroundThe lifetime risk of suicide in affective disorders is commonly quoted as 15%. This stems from hospital populations of affective disorders.AimsTo model the lifetime prevalence of suicide using data on completed suicides from one English Health District and community-based rates of prevalence of affective disorders.MethodsA secondary analysis of a primary data set based on 212 suicides in North Staffordshire was undertaken. The population rates of psychiatric morbidity were obtained from the National Comorbidity Survey.ResultsThe model suggests a lifetime prevalence rate of suicide for any affective disorder at 2.4%, with a rate for those uncomplicated by substance abuse, personality disorder or non-affective psychosis at 2.4%, and a rate for uncomplicated cases who had no mental health service contact at 1.1%.ConclusionsLifetime prevalence rates of suicide in subgroups of affective disorders may be lower than the traditional rates cited for hospital depression. This has implications for primary care projects designed to investigate the occurrence of and the prevention of suicide.

scholarly journals Recent advances in understanding antiphospholipid syndrome

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2908 ◽  
Author(s):  
Maria Laura Bertolaccini ◽  
Giovanni Sanna
Keyword(s):  
Antiphospholipid Syndrome ◽  
Antiphospholipid Antibodies ◽  
Anticardiolipin Antibodies ◽  
Coagulation Cascade ◽  
Systemic Autoimmune Disease ◽  
Vascular Thrombosis ◽  
Clinical Criteria ◽  
Pregnancy Morbidity ◽  
Glycoprotein I ◽  
Hughes Syndrome

Antiphospholipid syndrome (APS), also known as Hughes Syndrome, is a systemic autoimmune disease characterized by thrombosis and/or pregnancy morbidity in the presence of persistently positive antiphospholipid antibodies. A patient with APS must meet at least one of two clinical criteria (vascular thrombosis or complications of pregnancy) and at least one of two laboratory criteria including the persistent presence of lupus anticoagulant (LA), anticardiolipin antibodies (aCL), and/or anti-b2 glycoprotein I (anti-b2GPI) antibodies of IgG or IgM isotype at medium to high titres in patient’s plasma. However, several other autoantibodies targeting other coagulation cascade proteins (i.e. prothrombin) or their complex with phospholipids (i.e. phosphatidylserine/prothrombin complex), or to some domains of β2GPI, have been proposed to be also relevant to APS. In fact, the value of testing for new aPL specificities in the identification of APS in thrombosis and/or pregnancy morbidity patients is currently being investigated.

Antiphospholipid syndrome (Hughes syndrome): 10 clinical topics

Lupus ◽  
2010 ◽  
Vol 19 (4) ◽  
pp. 343-346 ◽  
Author(s):  
GRV Hughes
Keyword(s):  
Antiphospholipid Syndrome ◽  
Clinical Picture ◽  
Antiphospholipid Antibodies ◽  
International Congress ◽  
Short Contribution ◽  
Clinical Observations ◽  
The Subject ◽  
Hughes Syndrome

This year in Galveston, Texas, Silvia Pierangeli hosts the 13th International Congress on Antiphospholipid Antibodies. Twenty-six years after the first antiphospholipid syndrome meeting, the number of interested colleagues has multiplied, and the subject has become more scientifically understood. So also has the clinical picture. In this short contribution, I will highlight a number of clinical observations which may, or may not, contribute to our understanding of antiphospholipid syndrome.

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