Realizing the Effective Detection of Tumor in Magnetic Resonance Imaging using Cluster-Sparse Assisted Super-Resolution

Recently, significant research has been done in Super-Resolution (SR) methods for augmenting the spatial resolution of the Magnetic Resonance (MR) images, which aids the physician in improved disease diagnoses. Single SR methods have drawbacks; they fail to capture self-similarity in non-local patches and are not robust to noise. To exploit the non-local self-similarity and intrinsic sparsity in MR images, this paper proposes the use of Cluster-Sparse Assisted Super-Resolution. This SR method effectively captures similarity in non-locally positioned patches by training on clusters of patches using a self-adaptive dictionary. This method of training also leads to better edge and texture detection. Experiments show that using Cluster-Sparse Assisted Super-Resolution for brain MR images results in enhanced detection of lesions leading to better diagnosis.

Automated differentiation of Alzheimer’s condition using Kernel Density Estimation based texture analysis of single slice brain MR images

Computer-assisted tools can aid in the detection of Alzheimer disease (AD) which is a progressive neurodegenerative disorder that can lead to cognitive impairments and eventually death. The accumulated effects due to AD can cause changes in the appearance of grey matter, white matter and cerebrospinal fluid in brain Magnetic Resonance (MR) images. This study aims to use Kernel Density Estimation (KDE) technique to analyse the textural changes from single slice brain MR images for the detection of AD. The preprocessed, skull stripped T1-weighted MR brain images are obtained from the publicly available OASIS database. A single axial slice per subject is chosen from a volumetric image for further processing to reduce the computational load. Multivariate KDE technique is applied to each pixel, by considering the changes in the neighbourhood based on selected bandwidth to obtain corresponding density estimates. Statistical features quantifying the distribution of density estimates are extracted to characterise textural variations in images. Linear discriminant analysis (LDA) classifier is implemented with ten-fold cross-validation for detecting AD. An optimum bandwidth of 18 for the KDE technique is selected based on the classification performance. Out of seven extracted texture features, three are found to be statistically significant in distinguishing AD. The classification with LDA yields an accuracy of 72.3% with a sensitivity of 80.6% for identifying AD from healthy subjects. The proposed method is efficient in detecting AD by revealing the textural changes within the brain slice without the involvement of any segmentation technique. Thus, the novel KDE-based texture analysis proves to be an effective tool for the automated diagnosis of AD from single slice brain MR images.

Fasu-Net: Fast Alzheimer’s Disease Screening with Undersampled MRI Using Convolutional Neural Networks

Alzheimer’s Disease (AD) is a progressive and irreversible neurodegenerative condition, which results in dementia. Mild Cognitive Impairment (MCI) is an intermediate state between normal aging and AD. Instead of traditional questionnaire method, magnetic resonance imaging (MRI) can be used by radiologists to diagnose and screening AD recently, but long acquisition time is not conducive to screening AD and MCI. To solve this problem, we develop a Fasu-Net (Fast Alzheimer’s disease Screening neural network with Undersampled MRI) for AD and MCI clinical classification. The network uses undersampled structural MRI with a shorter acquisition time to improve the screening and diagnosis efficiency of AD. For achieving the best classification result, three axial planes of brain MR images were feed into the Fasu-Net with transfer learning method. The experiment results on undersampled 3D T1-weighted images database (ADNI) show that in the AD versus MCI versus HC (Healthy Controls) classification, the Fasu-Net achieved the accuracy of 91.41%, thus can be a potential method for fast clinical screening of AD.