Monitoring the Effect of Transdermal Drug Delivery Patches on the Skin Using Terahertz Sensing

Water content of the skin is an important parameter for controlling the penetration rate of chemicals through the skin barrier; therefore, for transdermal patches designed for drug delivery to be successful, the effects of the patches on the water content of the skin must be understood. Terahertz (THz) spectroscopy is a technique which is being increasingly investigated for biomedical applications due to its high sensitivity to water content and non-ionizing nature. In this study, we used THz measurements of the skin (in vivo) to observe the effect of partially and fully occlusive skin patches on the THz response of the skin after the patches had been applied for 24 h. We were able to observe an increase in the water content of the skin following the application of the patches and to identify that the skin remained hyper-hydrated for four hours after the removal of the fully occlusive patches. Herein, we show that THz spectroscopy has potential for increasing the understanding of how transdermal patches affect the skin, how long the skin takes to recover following patch removal, and what implications these factors might have for how transdermal drug patches are designed and used.

On-chip terahertz isolator with ultrahigh isolation ratios

Terahertz isolators, one of the typical nonreciprocal devices that can break Lorentz reciprocity, are indispensable building blocks in terahertz systems for their critical functionality of manipulating the terahertz flow. Here, we report an integrated terahertz isolator based on the magneto-optical effect of a nonreciprocal resonator. By optimizing the magneto-optical property and the loss of the resonator, we experimentally observe unidirectional propagation with an ultrahigh isolation ratio reaching up to 52 dB and an insertion loss around 7.5 dB at ~0.47 THz. With a thermal tuning method and periodic resonances, the isolator can operate at different central frequencies in the range of 0.405–0.495 THz. This on-chip terahertz isolator will not only inspire more solutions for integrated terahertz nonreciprocal devices, but also have the feasibility for practical applications such as terahertz sensing and reducing unnecessary reflections in terahertz systems.