Parametric Study of Proton Acceleration from Laser-Thin Foil Interaction

We experimentally investigated the accelerated proton beam characteristics such as maximum energy and number by varying the incident laser parameters. For this purpose, we varied the laser energy, focal spot size, polarization, and pulse duration. The proton spectra were recorded using a single-shot Thomson parabola spectrometer equipped with a microchannel plate and a high-resolution charge-coupled device with a wide detection range from a few tens of keV to several MeV. The outcome of the experimental findings is discussed in detail and compared to other theoretical works.

Application of an Ultrashort-pulsed Laser for Generation of Super-hydrophobic Surfaces

Hydrophobic surfaces have gained a vast attention in different fields of biomedical applications over the last few years. Laser treatment has been shown as a promising technology for the generation of functional, inter alia, superhydrophobic surfaces. In this study a picosecond Yb-YAG laser was assigned for the generation of superhydrophobic characteristics on a steel alloy with application in surgical instrumentation. Regarding the ablation energy threshold of about 6 μJ for the given pulse width and laser beam characteristics and by assigning a suitable combination of microstructure kinematics and laser processing conditions a persistent hierarchical pattern is mapped over the laser-radiated surfaces. The average measured contact angle on the laserradiated surfaces was about 150°, which indicates their superhydrophobic properties.

Deintensification Strategies Using Proton Beam Therapy for HPV-Related Oropharyngeal Cancer

Oropharyngeal cancers related to the human papillomavirus are a growing segment of head and neck cancers throughout the world. These cancers are biologically and demographically unique with patients presenting at younger ages and with more curable disease. This combination of factors heightens the importance of normal tissue sparing because patients will live a long time with treatment sequelae. Proton therapy has demonstrated benefits in reducing normal tissue exposure, which may lead to less toxicity, a higher quality of life, less immunologic suppression, and lower cost. Research investigating deintensified radiation volumes and doses are also underway. These deintensification studies synergize well with the beam characteristics of proton beam therapy and can decrease that already reduced normal tissue exposure enabled by proton therapy. Future studies should refine patient selection to best allow for volume and dose reduction paired with proton therapy.