Mulberry and Peppermint Leaves Mixing Ratio Optimization for Skin Beauty

Purpose: This study aims to determine the optimal mixing ratio of mulberry and peppermint leaves and evaluates their biological activities to identify whether the estimated ratio is suitable for use in inner beauty and cosmetic ingredients.Methods: Total polyphenol and flavonoid contents, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging activities, and tyrosinase and elastase inhibition activities were measured to optimize the mixing ratio of mulberry and peppermint leaves.Results: The mixture of mulberry and peppermint leaves showed a total polyphenol content of up to 46.58 mg TAE/g, a total flavonoid content of up to 45.54 mg QE/g, and DPPH and ABTS radical scavenging activities of up to 74.18% and 40.60%, respectively. Tyrosinase and elastase inhibition activities were up to 67.46% and 35.01%, respectively. In the interest section, the maximum antioxidant and tyrosinase inhibitory activities were obtained at a mulberry:pepperint mixing ratio of 1.49:0.75 (g:g). In the experimental section, the maximum antioxidant and tyrosinase inhibitory activities were obtained at a mulberry:pepperint mixing ratio of 1.79:0.80 (g:g). Further, the maximum antioxidant and elastase inhibitory activities were obtained at a mulberry:pepperint mixing ratio of 1.11:0.75 (g:g).Conclusion: This study determined the superiority of the antioxidant activity, tyrosinase and elastase activity inhibition efficacies, and optimal mixing ratios of mulberry and peppermint leaves. Based on our findings, we believe that mulberry and peppermint leaves at an optimal mixing ratio will have considerable use as inner beauty and cosmetic ingredients.

23. Damages

This chapter examines the entitlement of a claimant to recover damages in respect of a breach of contract committed by the defendant, and is organized as follows. Section 2 discusses the different measures of damages that can be awarded, while Section 3 analyses the performance interest. Section 4 examines the circumstances in which a claimant can seek damages based on his ‘reliance’ losses rather than his performance interest, while Section 5 discusses the circumstances in which damages may be awarded to protect the claimant’s ‘restitution’ interest. Section 6 examines the entitlement of a claimant to recover damages in respect of non-pecuniary losses, particularly ‘mental distress’. Section 7 considers the general rule that damages are assessed as at the date of breach and the exceptions to that rule, while Section 8 considers the various doctrines which the courts use in order to keep liability within acceptable bounds. These include remoteness, mitigation, and contributory negligence. Section 9 examines the circumstances in which a claimant can recover what is known as ‘negotiating damages’ or the defendant can be ordered to account to a claimant for the profits that he has made from his breach of contract. Section 10 looks at the possibility that exemplary damages might play a role in breach of contract cases. The chapter concludes, in Sections 11 and 12, with a discussion of agreed damages clauses (and related clauses) and their legal regulation.

A Patient perspective of Complementary and Integrative Medicine (CIM) for Migraine Treatment: A social media survey

OBJECTIVE: To survey persons with migraine who use social media about Complementary and Integrative Medicine (CIM) for the treatment of migraine.BACKGROUND: CIM encompasses medical treatments that are not part of ,but are used in concert with, mainstream medicine. Between 28–82% of people with migraine use non-drug approaches, and approximately 50% of people with migraine do not discuss non-drug treatments with their healthcare providers (HCPs) 9. it is important for providers to be conversant with CIM treatments and the available evidence-based data. To further this effort, the Complementary and Integrative Medicine Special Interest Section (CIMSIS) of the American Headache Society surveyed migraine patients directly through social media to identify CIM practices in which they engage.METHODS: In collaboration with the American Migraine foundation (AMF) and Yakkety Yak, a digital marketing agency, we posted a 17-question survey on the Move Against Migraine (MAM) Facebook group, which has 20,000 + members. The goals of the survey were to assess the attitudes toward CIM among this group, to identify which CIM modalities are being used and to determine what patients considered to be the most effective CIM modalities. While Yakkety Yak posted the survey link on the group page, the survey itself was hosted on Qualtrics, a confidential survey service. Qualtrics provides tools to configure survey properties and to customize privacy settings, so respondents cannot be tracked to an IP or email address, name or ticket number, which allows for anonymous responses. Our study was submitted for review to the IRB (institutional review board) and was exempted.RESULTS: 372 MAM members (approximately 2%) responded to the questionnaire, of which 335 reported using CIM; between 114–139 (34–42%) found CIM modalities to be at least mildly effective. Of note, 164 (49%) reported using cannabis derivatives or cannabinoids, specifically with, 64/164 (39%) reporting that cannabis was not effective for them.CONCLUSIONS: This study provides an initial investigation into the demographic and practice patterns of patients who use CIM. While it must this sampling may not reflect CIM use across all individuals with migraine, it does strongly suggest the need for better education on the role of, and evidence for, CIM among headache care providers, and the need to ask patients specifically about their use of and interest in CIM.

An overview of the Italian contribution to the international multisite SPRISTAD study on psychotherapy training

The Interest Section on Therapist Training and Development of the Society for Psychotherapy Research (SPRISTAD) has launched a multisite collaborative longitudinal study of psychotherapy trainees’ development, a large-scale study involving a number of countries all over the world. In the present article, we present an overview of the early Italian contribution to the SPRISTAD study, based on preliminary paper-and-pencil data collection. Our preliminary findings showed cross-sectional differences at different years of training and two-years longitudinal changes in trainees’ perceived development. Moreover, trainees’ characteristics such as their motivation, relational manner, current life, and personal background have shown to deserve attention in research on trainees’ development. These findings encourage the continuation of the SPRISTAD online data collection.

Review of International Law Stories (Laura A. Dickinson, Mark W. Janis, & John E. Noyes eds.)

Frederick W. Dingledy, International Law Stories, LH&RB: Newsletter of the Legal History & Rare Books Special Interest Section of the American Association of Law Libraries, Fall 2011, at 24 (book review).

Review of Linxia Liang, Delivering Justice in Qing China: Trials in the Magistrate's Court

Frederick W. Dingledy, Delivering Justice in Qing China: Trials in the Magistrate's Court, LH&RB: Newsletter of the Legal History & Rare Books Special Interest Section of the American Association of Law Libraries, Summer 2009, at 21 (book review).