pathogenic autoantibody
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2021 ◽  
Vol 118 (9) ◽  
pp. e1916337118
Author(s):  
Simone M. Brändle ◽  
Manuela Cerina ◽  
Susanne Weber ◽  
Kathrin Held ◽  
Amélie F. Menke ◽  
...  

Encephalitis associated with antibodies against the neuronal gamma-aminobutyric acid A receptor (GABAA-R) is a rare form of autoimmune encephalitis. The pathogenesis is still unknown but autoimmune mechanisms were surmised. Here we identified a strongly expanded B cell clone in the cerebrospinal fluid of a patient with GABAA-R encephalitis. We expressed the antibody produced by it and showed by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry that it recognizes the GABAA-R. Patch-clamp recordings revealed that it tones down inhibitory synaptic transmission and causes increased excitability of hippocampal CA1 pyramidal neurons. Thus, the antibody likely contributed to clinical disease symptoms. Hybridization to a protein array revealed the cross-reactive protein LIM-domain-only protein 5 (LMO5), which is related to cell-cycle regulation and tumor growth. We confirmed LMO5 recognition by immunoprecipitation and ELISA and showed that cerebrospinal fluid samples from two other patients with GABAA-R encephalitis also recognized LMO5. This suggests that cross-reactivity between GABAA-R and LMO5 is frequent in GABAA-R encephalitis and supports the hypothesis of a paraneoplastic etiology.


2018 ◽  
Vol 138 (5) ◽  
pp. S5
Author(s):  
L. Lin ◽  
B. Peng ◽  
T. Moran ◽  
J. Yang ◽  
D. Culton ◽  
...  

2017 ◽  
Vol 187 (9) ◽  
pp. 2020-2033 ◽  
Author(s):  
Shweta Jain ◽  
Jerrold M. Ward ◽  
Dong-Mi Shin ◽  
Hongsheng Wang ◽  
Zohreh Naghashfar ◽  
...  

Brain ◽  
2012 ◽  
Vol 135 (6) ◽  
pp. 1819-1833 ◽  
Author(s):  
Christina Elliott ◽  
Maren Lindner ◽  
Ariel Arthur ◽  
Kathryn Brennan ◽  
Sven Jarius ◽  
...  

Lupus ◽  
2009 ◽  
Vol 18 (13) ◽  
pp. 1176-1180 ◽  
Author(s):  
DS Pisetsky ◽  
IA Vrabie

Antibodies to DNA (anti-DNA) are the serological hallmark of systemic lupus erythematosus (SLE) and unique markers of the immunological disturbances critical to disease pathogenesis. In the form of immune complexes, anti-DNA autoantibodies can deposit in the tissue to incite inflammation and damage; in addition, these complexes can induce cytokine production, most prominently, type 1 interferon. Studies in both patients and animal models have implicated genetic as well as environmental factors in the aetiology of the anti-DNA response. Because bacterial DNA is a potent stimulant of innate immunity by both toll-like receptor (TLR) and non-TLR signalling pathways, foreign DNA introduced during the course of bacterial or viral infection could have a dual role in antibody induction. This DNA could serve as an adjuvant to activate innate immunity as well as an immunogen to drive an antigen-specific antibody response. In this scenario, the generation of cross-reactive autoantibodies, in contrast to highly specific antibodies to bacterial DNA, most likely depends on genetically determined abnormalities in the B-cell repertoire in patients with SLE. Given the universal expression of DNA, this model suggests that many different kinds of infections could trigger pathogenic autoantibody responses in SLE, as well as induce flare.


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