lateral linking
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Author(s):  
YAMIN WU ◽  
BIN LIAO ◽  
GUOLIANG WANG ◽  
BAOAN Bian

The effect of asymmetric lateral linking groups on the electronic transport is investigated in the biphenyl molecule-based device with gold electrodes with the framework of density functional theory and nonequilibrium Green’s function. The asymmetric lateral linking groups reduce the currents of molecular junctions, and result in the reverse rectifying behavior. The devices with asymmetric lateral linking groups –SH and –SCH3 have maximum rectifying ratios, while the asymmetric lateral linking group –SH and –NH2 cause minimum rectifying ratios. The calculated results suggest that the asymmetric lateral linking group induces the reduced coupling between molecule and right electrode, asymmetric distribution of frontier molecular orbital and asymmetric evolution of the molecular orbital eigenenergies, accounting for the rectifying behavior.


2021 ◽  
Vol 8 ◽  
Author(s):  
Lori K. Fenton ◽  
Simone Silvestro ◽  
Gary Kocurek

In Scandia Cavi on Mars, barchans migrating over a field of transverse aeolian ridges (TARs) leave behind distinctive trails (“wakes”) comprising both TARs undergoing exhumation and coarse-grained ripples being shed from the barchans. With distance upwind from the barchans, the combined pattern of these bedforms coarsens and defect density decreases, thus appearing to mature with exposure time. We present results of morphological analyses of the wake bedform crestlines using HiRISE images, seeking to determine how the wake pattern reflects TAR growth and pattern development. TARs interact with each other, exhibiting defect repulsions and possible lobe extensions, indicating that these bedforms have migrated in the past, despite the lack of identifiable change in overlapping images spanning 9.5 years. Mapping one wake in detail, we found that the TAR pattern is not affected by superposing ripples. However, the ripples undergo many interactions, first with one another, and later (with distance upwind) with the underlying TARs. Near the dune, many ripples laterally link, growing in length, and they preferentially form along TAR crests, resulting in small bedform repulsions and longer superposing ripples. Most of these ripples will be consumed by the TARs, an as-yet unreported growth dynamic for TARs that is consistent with the work of others, who have found a continuum between TARs and the meter-scale ripples that form on dunes. Constructing a DTM, orthorectifying HiRISE images, and measuring dune migration rates places the timescale of ripple absorption by TARs in a wake at several thousand years, with the first ∼1,000 years dominated by lateral linking of ripples. Assuming that TAR growth is accomplished entirely through dune burial and subsequent ripple consumption, we estimate a lower limit age of the TARs, and by extension, the dune field, to be ∼270 kyr.


2020 ◽  
Vol 220 (1) ◽  
Author(s):  
Yijun Zhang ◽  
Joachim Seemann

GRASP55 and GRASP65 have been implicated in stacking of Golgi cisternae and lateral linking of stacks within the Golgi ribbon. However, RNAi or gene knockout approaches to dissect their respective roles have often resulted in conflicting conclusions. Here, we gene-edited GRASP55 and/or GRASP65 with a degron tag in human fibroblasts, allowing for induced rapid degradation by the proteasome. We show that acute depletion of either GRASP55 or GRASP65 does not affect the Golgi ribbon, while chronic degradation of GRASP55 disrupts lateral connectivity of the ribbon. Acute double depletion of both GRASPs coincides with the loss of the vesicle tethering proteins GM130, p115, and Golgin-45 from the Golgi and compromises ribbon linking. Furthermore, GRASP55 and/or GRASP65 is not required for maintaining stacks or de novo assembly of stacked cisternae at the end of mitosis. These results demonstrate that both GRASPs are dispensable for Golgi stacking but are involved in maintaining the integrity of the Golgi ribbon together with GM130 and Golgin-45.


2020 ◽  
Author(s):  
Yijun Zhang ◽  
Joachim Seemann

AbstractGRASP65 and GRASP55 have been implicated in stacking of Golgi cisternae and lateral linking of stacks within the Golgi ribbon. However, loss of gene function approaches by RNAi or gene knockout to dissect their respective roles often resulted in conflicting conclusions. Here, we gene-edited GRASP55 and/or GRASP65 with a degron tag in human fibroblasts, allowing for the induced rapid degradation by the proteasome. We show that acute depletion of either GRASP55 or GRASP65 does not affect the Golgi ribbon, while chronic degradation of GRASP55 disrupts lateral connectivity of the Golgi ribbon. Acute double depletion of both GRASPs coincides with the loss of the vesicle tethering proteins GM130, p115 and Golgin-45 from the Golgi and compromises ribbon linking. Furthermore, neither GRASP55 and/or GRASP65 are required for maintaining stacks or de novo assembly of stacked cisternae at the end of mitosis. These results demonstrate that both GRASPs are dispensable for Golgi stacking, but are involved in maintaining the integrity of Golgi ribbon together with GM130 and Golgin-45.


2018 ◽  
Vol 213 ◽  
pp. 140-145 ◽  
Author(s):  
Jingjuan Yang ◽  
Xiaoxiao Han ◽  
Peipei Yuan ◽  
Baoan Bian ◽  
Yapeng Zheng ◽  
...  

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