The roots, leaves and seeds of ambrette are considered as valuable traditional medicines. The bitter, sweet, acrid, aromatic seeds are used as tonic and are considered to possess cooling, aphrodisiac, ophthalmic, cardiotonic, digestive, stomachiecm carminative, pectoral diuretic, stimulant, antispasmodic and deodorant properties. Crop removes nutrients continuously from soil and therefore, their replenishment though fertilizers and manures are essential. To find out the integrated effect of inorganic fertilizers, neem coated urea, enriched pressmud compost and sea weed extract on NPK uptake by ambrette and its post – harvest soil NPK status, a field investigation was carried out at Farmer’s Field Sivapuri Village, Chidambaram Taluk, Cuddalore District during Kharif, 2018. The experiment was laid out in Randomized Block Design (RBD) with eight treatments and three replications. The crop was grown to maturity with proper cultural practices. The results revealed that application of integrated application of inorganic fertilizers, neem coated urea, enriched pressmud compost and sea weed extract resulted in significantly highest NPK uptake by ambretee and influenced the post – harvest soil fertility status with respect to available NPK.