Mangostanaxanthone VII, a new cytotoxic xanthone from Garcinia mangostana

Garcinia mangostana L. (the queen of fruits, mangosteen, family Guttiferae) is a wealthy source of xanthones. The CHCl3 soluble fraction of the air-dried pericarps of G. mangostana provided a new xanthone: mangostanaxanthone VII (5), along with four known xanthones: mangostanaxanthones I (1) and II (2), gartanin (3) and γ-mangostin (4). The structural verification of these metabolites was achieved by different spectral techniques, including UV, IR, 1D and 2D NMR and HRESIMS. The new metabolite was assessed for cytotoxic potential, using sulforhodamine B (SRB) assay towards the A549 and MCF-7 cancer cell lines. Moreover, its antimicrobial effects were evaluated against various bacterial and fungal strains, using agar disc diffusion assay. Mangostanaxanthone VII showed moderate cytotoxic activity against the A549 and MCF7 cell lines with IC50s 26.1 and 34.8 μM, respectively, compared with doxorubicin (0.74 and 0.41 μM, respectively).

EVALUATION OF ANTIMICROBIAL AND SYNERGISTIC ANTIMICROBIAL PROPERTIES OF PTEROCARPUS SANTALINUS

Objectives: The aim of the present study was to evaluate antibacterial and synergistic antimicrobial properties of leaf, stem and bark of Pterocarpus santalinus. Methods: The extraction was done by decoction method. The antimicrobial activity was done by agar well diffusion assay and the synergistic antimicrobial activity was done by agar disc diffusion assay. Results: The synergistic activity was studied with plant extracts plus antibiotics viz. Ampicillin , Polymyxin-B, Clotrimazole and Fluconazole. Conclusions: Amongst the three parts, the best antimicrobial activity was shown by bark extract. All the three parts showed synergistic antimicrobial activity with antibiotics but their level varied. The results suggest that all the three parts phytochemicals that enhance the antimicrobial efficacy of the antibiotics against some microorganisms and hence can be developed as a new therapeutic weapon against infectious diseases.