The Impact of “Strike Hard” on Repeat and Near-Repeat Residential Burglary in Beijing

“Strike Hard” is an enhanced law-enforcement strategy in China that aims to suppress crime, but measurement of the crime-reducing effect and potential changes in the spatiotemporal concentration of crime associated with “Strike Hard” remain unknown. This paper seeks to examine the impact, if any, of “Strike Hard” on the spatiotemporal clustering of burglary incidents. Two and half years of residential burglary incidents from Chaoyang, Beijing are used to examine repeat and near-repeat burglary incidents before, during, and after the “Strike Hard” intervention and a new technique that enables the comparison of repeat and near repeat patterns across different temporal periods is introduced to achieve this. The results demonstrate the intervention disrupted the repeat pattern during the “Strike Hard” period reducing the observed ratio of single-day repeat burglaries by 155%; however, these same single-day repeat burglary events increased by 41% after the cessation of the intervention. Findings with respect to near repeats are less remarkable with nominal evidence to support that the intervention produced a significant decrease, but coupled with other results, suggest that spatiotemporal displacement may have been an undesired by-product of “Strike Hard”. This study from a non-Western setting provides further evidence of the generalizability of findings related to repeat and near repeat patterns of burglary and further highlights the limited preventative effect that the “Strike Hard” enhanced law enforcement campaign had on burglary.

Systems-Level Analysis of Genome-Wide Association Data

Genome-wide association studies (GWAS) have emerged as the method of choice for identifying common variants affecting complex disease. In a GWAS, particular attention is placed, for obvious reasons, on single-nucleotide polymorphisms (SNPs) that exceed stringent genome-wide significance thresholds. However, it is expected that many SNPs with only nominal evidence of association (e.g., P < 0.05) truly influence disease. Efforts to extract additional biological information from entire GWAS datasets have primarily focused on pathway-enrichment analyses. However, these methods suffer from a number of limitations and typically fail to lead to testable hypotheses. To evaluate alternative approaches, we performed a systems-level analysis of GWAS data using weighted gene coexpression network analysis. A weighted gene coexpression network was generated for 1918 genes harboring SNPs that displayed nominal evidence of association (P ≤ 0.05) from a GWAS of bone mineral density (BMD) using microarray data on circulating monocytes isolated from individuals with extremely low or high BMD. Thirteen distinct gene modules were identified, each comprising coexpressed and highly interconnected GWAS genes. Through the characterization of module content and topology, we illustrate how network analysis can be used to discover disease-associated subnetworks and characterize novel interactions for genes with a known role in the regulation of BMD. In addition, we provide evidence that network metrics can be used as a prioritizing tool when selecting genes and SNPs for replication studies. Our results highlight the advantages of using systems-level strategies to add value to and inform GWAS.