Particular neurophysiological aspects of etiopathogenesis of juvenile idiopathic scoliosis

Aim. To study the data of mathematical model of mismatch between the vertebral length and the spinal cord calculated length in adolescents with juvenile idiopathic scoliosis. Materials and methods. The paper presents the data on the calculated value of spinal cord and vertebral growth mismatch coefficient according to computed optic tomography and transcranial magnetic stimulation data in 46 adolescents, suffering from multiplane vertebral deformity of different degree of severity. Results. The obtained data confirm the theory of mismatch between the spinal cord and vertebral growth. It was shown that spinal cord growth is the process, which does not depend on patients age and length of vertebral column. Conclusions. There was constructed a mathematical 3D-model of link between the multiplane deformity severity, age and spinal cord and vertebral growth mismatch coefficient value, which can serve as a perceptive prognostic instrument in diagnosis of idiopathic scoliosis.

Validation of the Essen Stroke Risk Score and the Stroke Prognosis Instrument II in Chinese Patients

Background and Purpose— Little was known about the predictive accuracy of the Essen Stroke Risk Score and the Stroke Prognostic Instrument II in Chinese patients with stroke. Methods— We evaluated the predictive accuracy of both Essen Stroke Risk Score and Stroke Prognostic Instrument II scores for both recurrent stroke and combined vascular events using data from a prospective cohort of 11 384 patients with acute ischemic stroke and transient ischemic attack admitted to 132 urban hospitals throughout China. Results— The cumulative 1-year event rates were 16% (95% CI, 15%–16%) for recurrent stroke and 18% (95% CI, 18%–19%) for combined vascular events. Both event rates were significantly higher in patients with transient ischemic attack and increased significantly from lower to higher Essen Stroke Risk Score and Stroke Prognostic Instrument II categories. Essen Stroke Risk Score and Stroke Prognostic Instrument II had similar predictive accuracies for each study outcome. Conclusions— In Chinese patients with ischemic stroke or transient ischemic attack, both Essen Stroke Risk Score and Stroke Prognostic Instrument II scores are equally able to stratify the risk of recurrent stroke and combined vascular events.