The effect of sclerotherapy and pre-pregnancy training with inositol and vitamin D3 on the size and number of cysts in women with infertility on the background of endometriosis

Annotation. Among gynecological diseases, external genital endometriosis leads to disorders of reproductive function and promotes the development of infertility. Currently, the search for less traumatic and more effective treatments for endometriosis continues. The aim of our study was to analyze the diameter of endometrioid cysts in women with infertility on the background of endometriosis before and after sclerotherapy using pre-pregnancy preparation of a complex vitamin preparation with inositol and vitamin D3. The study included 105 women aged 22 to 40 years with endometriosis-associated infertility. The presence of cysts was confirmed by ultrasound and bimanual examination. The drug FT 500 plus was prescribed in a dosage of 1 sachet – once a day from the 2nd or 3rd day of the cycle for 2 menstrual cycles (the cycle in which sclerotherapy was performed and the next cycle). Vitamin D3 “EuTilia D3” was prescribed in prophylactic doses of 2000 IU to women, or therapeutic (depending on the diagnosed or refuted diagnosis of vitamin D hypovitaminosis). The sclerotherapy procedure was performed by transvaginal puncture of the cyst and aspiration of its contents under the control of transvaginal ultrasound, introduction into the capsule of the cyst (without violating its integrity) 76% ethanol solution. It was found that women with endometriosis-associated infertility, who underwent pre-pregnancy preparation with a complex vitamin preparation with inositol and vitamin D3 after sclerotherapy, probably decreased the diameter of cysts in the right (5.85 times) and left (5.57 times) ovaries relative to data before sclerotherapy. When comparing the diameter of cysts in women who underwent pre-pregnancy preparation with a complex vitamin preparation with inositol and vitamin D3, depending on the type of surgery (sclerotherapy or cystectomy) found a probable decrease in the diameter of cysts after sclerotherapy in the right (82.89%) and left (82.05%) ovaries for such data after cystectomy. Therefore, sclerotherapy with pregravidar preparation with a complex vitamin preparation with inositol and vitamin D3 in women with endometriosis-associated infertility probably reduces the diameter of cysts relative to the experimental group without pregravidar preparation, as well as to the group with a history of cystectomy.

Treatment of cats for associated bordetellosis in the private sector of Poltava

For suspicion of an infectious disease of cats, diagnostic tests were conducted. From the purulent leakages of the nasal cavity of the cat, pure cultures of the Bordetal, Escherichia and Staphylococcus cultures were obtained. Differential environments were used for this purpose. For effective treatment, each of the isolated cultures was tested for antibacterial sensitivity. According to the results, isolated cultures showed the highest sensitivity to gentamicin and enrofloxacin. Given the sensitivity of the isolated microflora, enrofloxacin-50 was used in the range of 0.1 ml per 1 kg of body weight for 5 days subcutaneously. Cats are a kind of animals that are sensitive to antibacterial substances. The choice of enrofloxacin was due to the lack of reactions and sensitivity to this drug in cats. As the immunomodulatory agents, which increase the overall resistance of the body used Katozal and Gamavat. Katozal was used for cats once a day subcutaneously for 5 days, at a dose of 0.5 ml for 5 days. Gamavit was administered subcutaneously at a dose of 0.3–0.5 ml/kg body weight (therapeutic dose). Tetravit was used as a vitamin preparation. It was injected subcutaneously 0.3 ml; once in 7 days. Improvement of the clinical condition of the diseased animal was observed the second day after the start of treatment; the animal revived, appetite appeared, the mucus-purulent discharge from the nasal cavity stopped. As bordeliosis is transmitted by airborne droplet, air disinfection was carried out using a bactericidal irradiator BactoSfera OBB 36 P with a quartz lamp. To disinfect the bactericidal lamp was switched on every day – in the morning and evening for 20 minutes.