The Regulation of Circulating Hepatokines by Fructose Ingestion Levels in Humans

Background Fibroblast growth factor 21 (FGF21), follistatin, angiopoietin-like 4 (ANGPTL4) and growth differential factor 15 (GDF15) are regulated by the energy metabolism. Recent findings in humans demonstrate that fructose ingestion increases circulating FGF21 with increased response in conditions of insulin resistance. Objective to study the acute effect of fructose and somatostatin on circulating FGF21, follistatin, ANGPTL4 and GDF15 in humans. Methods Plasma FGF21, follistatin, ANGPTL4 and GDF15 concentrations were measured in response to oral ingestion of 75g of fructose in 10 young healthy males with and without a 15-minute infusion of somatostatin to block insulin secretion. A control infusion of somatostatin was also performed in the same subjects. Results Following fructose ingestion, plasma FGF21 peaked at 3.7-fold basal concentration (p<0.05) and increased 4.9-fold compared with basal concentration. (p<0.05) when somatostatin was infused. Plasma follistatin increased 1.8-fold after fructose ingestion (p<0.05), but this increase was blunted by concomitant somatostatin infusion. For plasma ANGPTL4 and GDF-15, no increases were obtained following fructose ingestion. Infusion of somatostatin alone slightly increased plasma FGF21 and follistatin. Conclusions Here we show in humans that 1) the fructose-induced increase in plasma FGF21 was enhanced when somatostatin was infused suggesting an inhibitory role of insulin on the fructose-induced FGF21 increase; 2) fructose ingestion also increased plasma follistatin, but somatostatin infusion had no effect on the increase; 3) fructose ingestion had no stimulating effect on ANGPTL4 and GDF15 levels demonstrating differences in the hepatokine response to fructose ingestion.

Prototype Sistem Monitoring Infus Berbasis IoT (Internet of Things)

The development of increasingly sophisticated medical science and technology has an impact on the development of science and technology in the field of medical-devices. One of the existing equipment and is often used in hospitals, one of which is an IV. Currently in the world of health, infusion is still controlled manually. Because it takes time if the nurse has to go back and forth throughout the patient room. Not only is it time consuming, but there will be risks if it is too late to treat a patient whose infusion has run out. Technology needs to be used to minimize risks in the medical world, one of which is the application of IoT technology. This study aims to make it easier for nurses to control infusion conditions in real time using the concept of IoT ( the Internet of Things). The method used is the Waterfall method. This research uses hardware consisting of Load Cell with the HX711 module as a weight sensor, NodeMCU V3 as a processor, and Thingspeak Web server as the interface with the user. The results of the measurement of the tool made have an error of 0.25 Gram, sending data to the Thingspeak.com Server requires a good connection for maximum results.

Panendoscopy and Anaesthesia for Debulking of Juvenile Onset Recurrent Respiratory Papillomata (RRP) Using Target control Infusion (TCI) and Manujet 3 for High Pressure Source Ventillation (HPSV)

Laryngeal papilloma can cause respiratory difficulties and obstruction. Diagnosis of laryngeal papillomata is often delayed as other childhood illnesses are excluded. Anaesthesia involving TCI and jet ventilation using (HPSV) for the surgical debulking of laryngeal papillomata is a good technique in procedures involving a shared airway