intracavernous injections
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2020 ◽  
Vol 61 (1) ◽  
pp. 88
Author(s):  
Jong Keun Kim ◽  
Myoung Jin Jang ◽  
Bo Hyun Kim ◽  
Ki Ryung Choi ◽  
Geehyun Song ◽  
...  

Author(s):  
Yurii Zasieda

Relevance. Some non-pharmacological methods, such as low-intensity pulsed ultrasound (LIPUS) proved to be effective in ED treatment due to stimulation of penile tissue regeneration and penile hemodynamics increase. The biological methods that utilize cellular growth factors such as platelet-rich plasma (PRP) therapy proved to be effective in stimulation of neovascularization processes and correction of endothelial dysfunction while ED treatment.Local negative pressure (LNP) therapy shall be considered as an auxiliary method to PRP and LIPUS due to its ability to slow down PRP outflow from injection zones. Sildenafil («Strondex») is perspective pharmacological addition to ED treatment protocol. Aim. Evaluation of the efficacy and safety of therapeutic model of combined application of PRP intracavernous injections, LNP, LIPUS and Sildenafil («Strondex») for vasculogenic (arterial and corporal veno-occlusive) ED treatment.Materials and methods. Prospective study was conducted in a group of 64 outpatients with diagnosis of erectile dysfunction of vascular genesis (ICD-10: N48.4) in Men’s Health Clinic (Kyiv, Ukraine). “International Index of Erectile Function-5” (IIEF-5), “Erectile Hardness Score” (EHS) were used as the tools for clinical assessment. Ultrasonic cavernous bodies scanning and pharmacodopplersonography were used for the data validation.Study results. Main group patients underwent treatment consisting of 6 sessions of PRP intracavernous injections and 12 sessions of local penile LIPUS combined with LNP and Sildenafil («Strondex») pharmacotherapy. Control group underwent 12 sessions of local penile LIPUS combined with LNP and the same pharmacotherapy. According to the IIEF-5 data obtained 12 weeks after the study the erectile function improvement was found in 27 patients of the main group and 20 patients of the control group. EHS improved by 1 point or more in 29 and 20 patients correspondingly.Conclusions. Treatment protocol specifying combination of PRP, LIPUS, LNP and Sildenafil («Strondex») is promising due to PRP-therapy augmentation by intracavernous ultrasonic activation of platelet growth factors, but the data obtained require further physiological validation and clinical placebo-controlled studies with involvement of larger groups of population.


2018 ◽  
Vol 15 (7) ◽  
pp. S390
Author(s):  
E. Ventimiglia ◽  
L. Barbieri ◽  
P. Capogrosso ◽  
G. Gandaglia ◽  
F. Dehò ◽  
...  

2017 ◽  
Vol 3 (6) ◽  
pp. 643-645 ◽  
Author(s):  
René Yiou ◽  
Leila Hamidou ◽  
Brigitte Birebent ◽  
Dalila Bitari ◽  
Philippe Le Corvoisier ◽  
...  

2016 ◽  
Vol 59 ◽  
pp. e107
Author(s):  
Lucie Chochina ◽  
Florian Naudet ◽  
Isabelle Bonan ◽  
Clément Chehensse ◽  
Mireille Damphousse ◽  
...  

2016 ◽  
Vol 4 (3) ◽  
pp. 257-269 ◽  
Author(s):  
Lucie Chochina ◽  
Florian Naudet ◽  
Clément Chéhensse ◽  
Andrea Manunta ◽  
Mireille Damphousse ◽  
...  

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