Vaccinating adolescents against SARS-CoV-2 in England: a risk–benefit analysis

Objective To offer a quantitative risk–benefit analysis of two doses of SARS-CoV-2 vaccination among adolescents in England. Setting England. Design Following the risk–benefit analysis methodology carried out by the US Centers for Disease Control, we calculated historical rates of hospital admission, Intensive Care Unit admission and death for ascertained SARS-CoV-2 cases in children aged 12–17 in England. We then used these rates alongside a range of estimates for incidence of long COVID, vaccine efficacy and vaccine-induced myocarditis, to estimate hospital and Intensive Care Unit admissions, deaths and cases of long COVID over a period of 16 weeks under assumptions of high and low case incidence. Participants All 12–17 year olds with a record of confirmed SARS-CoV-2 infection in England between 1 July 2020 and 31 March 2021 using national linked electronic health records, accessed through the British Heart Foundation Data Science Centre. Main outcome measures Hospitalisations, Intensive Care Unit admissions, deaths and cases of long COVID averted by vaccinating all 12–17 year olds in England over a 16-week period under different estimates of future case incidence. Results At high future case incidence of 1000/100,000 population/week over 16 weeks, vaccination could avert 4430 hospital admissions and 36 deaths over 16 weeks. At the low incidence of 50/100,000/week, vaccination could avert 70 hospital admissions and two deaths over 16 weeks. The benefit of vaccination in terms of hospitalisations in adolescents outweighs risks unless case rates are sustainably very low (below 30/100,000 teenagers/week). Benefit of vaccination exists at any case rate for the outcomes of death and long COVID, since neither have been associated with vaccination to date. Conclusions Given the current (as at 15 September 2021) high case rates (680/100,000 population/week in 10–19 year olds) in England, our findings support vaccination of adolescents against SARS-CoV2.

Tessier 30 Facial Clefts—A Literature Review of 72 Cases (1996-2020), Suggested Treatment Protocol, Outcome Measures, Minimum Dataset for Future Case Reports, and Registries

Introduction: Tessier 30 facial cleft is a rare anomaly presenting in the soft and hard tissues over the central lower face. Owing to the rarity of cases and difficulty of treatment, there is no universally accepted surgical management strategy. The last comprehensive literature review of Tessier 30 clefts was in 1996. This report aims to update the literature to inform decision-making on treating Tessier 30 cases. Methodology: A literature search was performed. PubMed, SCOPUS, and OVID databases were searched. A total of 72 cases in 51 articles were analyzed, looking at demographics, extent of cleft, parent health, family history, procedures, follow-up, existence of other anomalies, and stages of repair. Results: Surgeons are increasingly choosing to repair Tessier 30 defects in one rather than multiple stages. Of the 72 cases studied, only 31 had documented the completed repair of the cleft. All completed soft tissue only defects were repaired in 1 stage of repair (n = 11). Where both soft tissue and mandible was involved (n = 20), 55% (n = 11) had undergone 1-stage repair to address the Tessier 30 cleft. Discussion: We argue that a single-stage approach is preferable to multistage. Primary mucogingivoperiosteoplasty should be undertaken in children at the time of management of the soft tissue cleft. The timing of this procedure should be in the latter half of the first year of life, as this is when mandibular symphyseal fusion normally occurs. We have suggested a treatment protocol and we hope that future case reports use our minimum data set.

Variation of insect succession in summer on decomposing rabbit carrions treated with aluminum phosphide in Beheira governorate, Egypt

The present study aimed to record the arthropod fauna of medico-legal importance in an urban city: El Delengat, Beheira governorate, Egypt, by studying the succession of insects and the duration of the decomposition of rabbit carrions injected with Aluminum phosphide (AlP). In our study the total of twelve male rabbits, Oryctolagus cuniculus L, each weighing 1,25 kg were used. The experiment was conducted in summer. Three replicate experiments were conducted, for each experiment, 3 rabbits were administered intragastrically dosages of 27.4 mg, 13.7 mg, 54.8 mg of aluminum phosphide by body weight representing LD50, ½ LD50, 2 LD50, respectively. The fourth rabbit was used as a control, injected by saline solution. The recorded entomofauna was denoted in 5 orders, 12 families, and 17 genera and species. Necrophagous arthropods that colonized rabbit carrions were substantially of Diptera and Coleoptera orders. Calliphorid insects was the foremost family that colonizing the different carrions. AlP appeared to delay the decomposition process in ½ LD50 and 2 LD50 carrions. These results are the primary record of the arthropod successive pattern on aluminum phosphide remains, it will provide useful data in any future case studies involving AlP intoxication.

Measuring productivity of dairy industry companies: an approach with data envelopment analysis

PurposeThis research had two main objectives: To measure the productivity of companies in the Colombian dairy industry and to identify efficient decision-making units (DMUs) that can be used as work sample in future case studies.Design/methodology/approachIn the measurement of productivity, financial variables were considered for a sample of 19 DMUs. Efficient companies were identified through the data envelopment analysis (DEAs) methodology with the VRS model oriented to inputs and outputs. The input variables analyzed were “current asset,” “property, plant and equipment,” “non-current liability” and “equity,” while the output variables were “revenue” and “profit.”FindingsFindings revealed that seven DMUs are efficient in the input and output orientation and that companies of different sizes and with or without quality certifications are efficient in the sample analyzed. Additionally, the benchmark efficient DMUs were identified for each of the non-efficient DMUs.Research limitations/implicationsThe implications for the research include the contribution to the theory, on the one hand, with the analysis of the current state of the literature on the use of DEA in the food sector, and on the other, with the use of DEA to measure the productivity of Colombian dairy industry companies and with the identification of a sample of efficient units that can be analyzed in future case studies.Originality/valueThis article is novel and pioneering because it measures for the first time the productivity of DMUs of the Colombian dairy industry, in addition to including the current state of the literature on the application of the DEA methodology in the food sector. These findings contribute to the consolidation of the theory and also provide inputs for researchers, practitioners, managers, and policy makers.