Sensitivity and specificity 340
Calculations for sensitivity and specificity 342
Effect of prevalence 344
Likelihood ratio, pre-test odds, post-test odds 346
Receiver operating characteristic (ROC) curves 348
Links to other statistics 350
In this chapter we describe how statistical methods are used in diagnostic testing to obtain different measures of a test’s performance. We describe how to calculate sensitivity, specificity, and positive and negative predictive values, and show the relevance of pre- and post-test odds and likelihood ratio in evaluating a test in a clinical situation. We also describe the receiver operating characteristic curve and show how this links with logistic regression analysis. All methods are illustrated with examples....