Here, a graph-theoretic approach is applied to some problems in networks, for example in wireless sensor networks (WSNs) where some sensor nodes should be selected to behave as a backbone/dominating set to support routing communications in an efficient and fault-tolerant way. Four different types of multiple domination (k-, k-tuple, α- and α-rate domination) are considered and recent upper bounds for cardinality of these types of dominating sets are discussed. Randomized algorithms are presented for finding multiple dominating sets whose expected size satisfies the upper bounds. Limited packings in networks are studied, in particular the k-limited packing number. One possible application of limited packings is a secure facility location problem when there is a need to place as many resources as possible in a given network subject to some security constraints. The last section is devoted to two general frameworks for multiple domination: <r,s>-domination and parametric domination. Finally, different threshold functions for multiple domination are considered.