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Published By Springer-Verlag

2167-4841

Author(s):  
Sanaa Mahmoud ◽  
Mostafa El-Kalliny ◽  
Alyaa Kotby ◽  
Mona El-Ganzoury ◽  
Eman Fouda ◽  
...  

Abstract Purpose of Review Different treatment approaches have been described for the management of COVID-19-related multisystem inflammatory syndrome in children (MIS-C), the pathogenesis of which has not yet been fully elucidated. Here, we comprehensively review and summarize the recommendations and management strategies that have been published to date. Recent Findings MIS-C patients are treated with different regimens, mostly revolving around the use of immunomodulatory medications, including IVIG and glucocorticoids as first-tier therapy. Refractoriness to IVIG and glucocorticoids warrants a step-up of immunomodulatory therapy to biologic agents such as anakinra, tocilizumab, and infliximab. Summary We review the current evidence regarding the use of monotherapy versus combination therapy, as well as the current recommendations for assessing thrombotic risk and administering antiplatelet and anticoagulant therapy. We anticipate that future studies will provide evidence for management plans that maximize short- and long-term outcomes.


Author(s):  
Preeti M. Galagali ◽  
Sreyoshi Ghosh ◽  
Hemant Bhargav
Keyword(s):  

Author(s):  
Charushree Prasad ◽  
Jenna Mistry ◽  
Seetha Radhakrishnan
Keyword(s):  

Author(s):  
Guido Filler ◽  
Fabio Salerno ◽  
Christopher William McIntyre ◽  
Maria E. Díaz-González de Ferris

Author(s):  
María Celeste Savignano ◽  
Graciela Kondratiuk ◽  
María de las Mercedes Martínez ◽  
Pablo Lechuga ◽  
Florencia Ugo ◽  
...  

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