Comparative study of diagnostic value between IVIM and DWI for prostate cancer at 3.0 T magnetic resonance

Objective To quantitatively compare the diagnostic and differential diagnostic value of intra-voxel incoherent motion imaging (IVIM) and diffusion weighted imaging (DWI) for prostate cancer (PCa) and benign prostatic hyperplasia (BPH). Methods 68 cases of prostate confirmed by pathology, including 33 cases of PCa and 35 cases of BPH were analyzed retrospectively. All patients were underwent T1WI, T2WI, DWI and IVIM sequences to obtain the apparent diffusion coefficient (ADC), pure apparent diffusion coefficient (Pure-ADC/D), standard apparent diffusion coefficient (standard-ADC/Ds), fast apparent diffusion coefficient (fast-ADC/D*), fraction of fast apparent diffusion coefficient (f) values. All the multiple parameters were statistically analyzed for the differential diagnosis of BPH and PCa. P < 0.05 was considered as statistically significant. Results The differences in D, Ds, f and ADC values between BPH and PCa groups were statistically significant (all P values < 0.001), respectively. Among them, D value in the IVIM model had the highest diagnostic efficiency for PCa, the area under the curve (AUC) was 0.967, and the AUC combined with the ADC value and D value reaches 0.973. Conclusion The diagnostic efficacy of multiple parameters in the IVIM model for PCa was higher than the ADC value of the quantitative parameter of DWI. D value had the highest diagnostic efficiency. The combined diagnosis of ADC and D value was more effective, more advantageous in the diagnosis and differential diagnosis of PCa.