In the chapter we discuss Meaning Equivalence Reusable Learning Objects (MERLO), a multi-dimensional database that allow sorting and mapping of important concepts in a given knowledge domain through multi-semiotic representations in multiple sign systems, including: exemplary target statements of particular conceptual situations, and relevant other statements. MERLO pedagogy guides sequential teaching/learning episodes in a course by focusing learners' attention on meaning. The format of MERLO assessment item allow the instructor to assess deep comprehension of conceptual content by eliciting responses that signal learners' ability to recognize, and to produce, multiple representations, in multiple sign-systems - namely, multi-semiotic - that share equivalence-of-meaning. Exposure of scholars and learners to multi-semiotic inductive questions enhance cognitive control of inter-hemispheric attentional processing and enhance higher-order thinking. It highlights the important role of representational competence in scholarship, teaching and learning.