This chapter will describe the interrelationship between ICT, total relationship medicine approach, 5 Q and reducing medical errors and increasing patient safety. Medical errors are one of the Nation's leading causes of death and injury. A report published in 2000 by the Institute of Medicine (IOM) estimates that as many as 44,000 to 98,000 people die in U.S. hospitals each year as the result of medical errors. By 2004 the result was 195000 die and 1 000 000 excess injures by the medical errors. This means that more people die from medical errors than from motor vehicle accidents, breast cancer, or AIDS. Few studies have been conducted to investigate the link between technological, technical and functional quality dimensions and the level of patient's safety, medical errors and patient satisfaction in the healthcare sector. None of the identified studies have empirically examined how the atmosphere, interaction and infrastructure which focuses on availability of technology might prevent the medical errors and impact overall patient's quality perception and satisfaction.