Rorty and Peirce

This chapter presents a fuller, more accurate picture of Rorty’s early appreciation for and indebtedness to Peirce by establishing that Rorty was, by his own lights, at least for a time, a Peircean realist. This distinctive “Peircean” version of realism illuminates Rorty’s mature positions later expressed via a Davidsonian vocabulary. It also recounts how Rorty’s reading of Peirce’s end of inquiry and normative theory of self-controlled conduct enables him to grasp the dependence of epistemology on ethics and to see philosophical discourse as a rule-governed realm that necessitates choice of vocabulary and hence responsibility. Rorty turns out to be more of a realist, as traditionally understood, and Peirce less of one than we might expect. The “ethically-centered epistemology” aimed at the growth of knowledge Rorty sees in Peirce contrasts sharply with the view dominant among contemporary Peirceans, like Misak and Talisse, preoccupied above all with justification.

Developing the Competences of Generation Z with Innovative Teaching Methods in the Context of the Requirement of Labour Market by Industry 4.0

The advent of the 4. Industrial Revolution brings new opportunities, but also risks to entrepreneurs and employees as well as to education systems and the methods of teaching the present generation in education system. New job opportunities, new forms of work bring demands both from practice and from individual point of view, especially in terms of developing new competences and skills that are usable today. The scientific article is a partial output from the KEGA project 005UJS-4/2019 entitled “Streamlining Managerial Sills of the generations Z and Y by gamification on the context of linking science and practice", which is solved at the Faculty of Economics of the J. Selye University in Komárno. The current period in which we live is influenced by the rapid growth of knowledge. The established methods and forms of teaching must be changed by the school that prepares the individual to be able to adapt to changing requirements. The impact of scientific and technological progress on education is a societal problem, where the contradiction between the amount of new knowledge in individual fields of science and the educational possibilities of the school has to be addressed. The main aim of our research is to point out the effective use of innovative teaching methods by application of gamification, which leads to the development of new competences in the generation Z, which will be easier to apply in the labour market.

Investigating Structural Property Relationships to Enable Repurposing of Pharmaceuticals as Zinc Ionophores

The importance of zinc in biology has gained greater recognition in recent years due to its essential contributions to the function of many endogenous enzymes. Disruption of zinc homeostasis may be useful in treating pathological conditions, such as Alzheimer’s, and for antiviral purposes. Despite the growth of knowledge and increased interest in zinc, little is known about the structure and function of zinc ionophores. In this study we analyse the Cambridge Structural Database and solution complexation studies found in the literature to identify key functional groups which may confer zinc ionophorism. Pharmaceuticals, nutraceuticals and amino acids with these functionalities were selected to enable us to explore the translatability of ionophoric activity from in vitro assays to cellular systems. We find that although certain species may complex to zinc in the solid and solution states, and may carry ions across simple membrane systems, this does not necessarily translate into ionophoric activity. We propose that the CSD can help refine key functionalities but that ionophoric activity must be confirmed in cellular systems.

The role of TGF-β or BMPR2 signaling pathway-related miRNA in pulmonary arterial hypertension and systemic sclerosis

Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue disease (CTD), causing death in systemic sclerosis (SSc). The past decade has yielded many scientific insights into microRNA (miRNAs) in PAH and SSc. This growth of knowledge has well-illustrated the complexity of microRNA (miRNA)-based regulation of gene expression in PAH. However, few miRNA-related SSc-PAH were elucidated. This review firstly discusses the role of transforming growth factor-beta (TGF-β) signaling and bone morphogenetic protein receptor type II (BMPR2) in PAH and SSc. Secondly, the miRNAs relating to TGF-β and BMPR2 signaling pathways in PAH and SSc or merely PAH were subsequently summarized. Finally, future studies might develop early diagnostic biomarkers and target-oriented therapeutic strategies for SSc-PAH and PAH treatment.

Towards the Energy Transition of the Building Stock with BIPV: Innovations, Gaps and Potential Steps for a Widespread Use of Multifunctional PV Components in the Building Envelope

The scenario that emerges from scientific research on the use of BIPV systems in architecture shows that photovoltaic technologies and systems have reached a significant development in production and installation, becoming a strategic approach in the field of energy efficiency and enabling a progressive decarbonisation of the building stock. Still, knowledge and methods of architectural integration are not fully developed, especially in Italy. The present paper reports the results of a research activity that, systematising the main criteria and indicators for assessing the integrability of BIPVs in architecture, has led to the development of BIPV Product and Case Study Catalogues that define an up-to-date state of the art on aspects of design and technological innovation using BIPV systems and components. Catalogues have been created with the objective of contributing to the growth of knowledge on the most up-to-date methods of design by implementing a ‘technology transfer’ from good practice, in which photovoltaic systems are an integral part of the design concept and construction techniques of the architecture. The analysis related to the production of BIPV systems and components and their application in architectural projects allows one to highlight the main critical factors in the diffusion throughout the country and to identify the main research demand arising from the specific national situation.

Modeling Cognitive System with Applied Machine learning in Additive Manufacturing using Fifth Generation Computer Systems

Data mining is known as data, which promotes the growth of knowledge discovery. It is the process of analyzing descriptive data from divergent perspectives and summarizing it into valuable information, which is high-level music processing out of which a machine intends to decipher the Raaga of a frequency or the pitch of the music. One of the ways to approach the task is by comparing selected music features from the spectrum and a Raaga database. Recognizing emotion from music has become one of the active research themes in image processing and applications based on human-computer interaction. This research conducts an experimental study on recognizing facial emotions. The flow of the emotion recognition system includes the basic process in the singular value decomposition system. These include music acquisition, pre-processing of a spectrum, feature detection, feature extraction, classification, and when the emotions are classified, the system assigns the particular user music according to his emotion. The proposed system focuses on live images taken from the music database. This research aims to develop an automatic music recognition system for innovative manufacturing through the additive manufacturing route. The emotions considered for the experiments include happiness, Sadness, Surprise, Fear, Disgust, and Anger that are universally accepted. This paper overviews the progress of applying Additive manufacturing in Applied Machine learning which sustains the capability of disruptive digital manufacturing.

Immunoglobulin A, an Active Liaison for Host-Microbiota Homeostasis

Mucosal surfaces in the gastrointestinal tract are continually exposed to native, commensal antigens and susceptible to foreign, infectious antigens. Immunoglobulin A (IgA) provides dual humoral responses that create a symbiotic environment for the resident gut microbiota and prevent the invasion of enteric pathogens. This review features recent immunological and microbial studies that elucidate the underlying IgA and microbiota-dependent mechanisms for mutualism at physiological conditions. IgA derailment and concurrent microbiota instability in pathological diseases are also discussed in detail. Highlights of this review underscore that the source of IgA and its structural form can dictate microbiota reactivity to sustain a diverse niche where both host and bacteria benefit. Other important studies emphasize IgA insufficiency can result in the bloom of opportunistic pathogens that encroach the intestinal epithelia and disseminate into circulation. The continual growth of knowledge in these subjects can lead to the development of therapeutics targeting IgA and/or the microbiota to treat life threatening diseases.

Emerging Technology Innovation in Gaza Strip Municipalities: An Entrepreneurial Approach

To boost corporate efficiency in both the public and private sectors, innovation is fundamental. Efficient technological transfer and the role of public-private sector collaboration play a major role in the modern growth of knowledge-based economies. As a public service organization, municipalities normally coordinate with all partners to draw up strategies and use them in communities. A new vision is needed for the Gaza Strip municipalities, where all public and private stakeholders work together to co-design and co-develop new cutting-edge products and services aimed at generating shared value through entrepreneurial behaviour. However, concrete examples of smart city projects revealed that municipalities often do not have the necessary capabilities as well as innovative approaches to collaborate with start-ups and other stakeholders’ ecosystems. So, this paper aims at analyzing (open) innovation in the municipal sector shedding lights on the barriers and challenges that municipalities in Gaza Strip face in smart city development. This study uses primary data gathered from various stakeholders through focus groups, semi-structured interviews and webinars to demonstrate how municipalities can work to address challenges in the smart city context, and to promote an ecosystem of entrepreneurship and innovation. Gaza Strip municipalities need to offer the necessary conditions for entrepreneurial talents who can bring their creative mindset, and technological experiences to the table, making it possible to build the best teams to solve any challenge. The research also concluded that Open Innovation Platforms can be seen as an important tool for enabling start-ups and researchers in developing emerging technologies.

A proposed strategic vision for the university's role in a changing world

In this study, the writer presents a set of the most important changes in the world from his view point, and the resulting problems or challenges. These changes are represented in the renewal of knowledge structures as a result of the rapid growth of knowledge, progress in technology and information systems, and the shift in the philosophy of science from science to science; To science for quality of life, and the shift from armed conflict in settling disputes, to peaceful negotiation and dialogue, and a broadening the view of the human environment from the local to the global. The writer deals with each of these changes by clarifying what is meant by it, and commenting on each change with his vision of the role that the university should play to confront it and solve the resulting problems. The writer concludes his study with a call to dialogue with those who agree with his vision or disagree with it.