Contemporary analytic philosophy is dominated by metaphilosophical naturalism, the view that philosophy ought to be in some sense continuous with science. According to contemporary naturalists, we cannot study the nature of mind, knowledge, language, meaning, and reality without taking into account the results from physics, linguistics, and the cognitive sciences. This chapter examines Quine’s evolving views on the relation between science and philosophy in 1950s and 1960s. Scrutinizing both the development of and the external responses to Word and Object, it examines how Quine became increasingly aware of the metaphilosophical implications of the views he had first developed in the late 1940s and early 1950s. In the final sections, this chapter offers a detailed reconstruction of Quine’s decision to label his position “naturalism.”