Staphylococcal scalded skin syndrome. Clinical features, pathogenesis, and recent microbiological and biochemical developments

1977 ◽  
Vol 113 (2) ◽  
pp. 207-219 ◽  
Author(s):  
P. M. Elias
Keyword(s):  
Clinical Features ◽  
Staphylococcal Scalded Skin Syndrome

Clinical, Microbial, and Biochemical Aspects of the Exfoliative Toxins Causing Staphylococcal Scalded-Skin Syndrome

1999 ◽  
Vol 12 (2) ◽  
pp. 224-242 ◽  
Author(s):  
Shamez Ladhani ◽  
Christopher L. Joannou ◽  
Denise P. Lochrie ◽  
Robert W. Evans ◽  
Susan M. Poston
Keyword(s):  
Clinical Features ◽  
Treatment Options ◽  
Entire Body ◽  
Secondary Complications ◽  
Staphylococcal Scalded Skin Syndrome ◽  
Treatment And Prevention ◽  
Causative Agents ◽  
Underlying Diseases ◽  
Disease Understanding ◽  
Significant Mortality

SUMMARY The exfoliative (epidermolytic) toxins of Staphylococcus aureus are the causative agents of the staphylococcal scalded-skin syndrome (SSSS), a blistering skin disorder that predominantly affects children. Clinical features of SSSS vary along a spectrum, ranging from a few localized blisters to generalized exfoliation covering almost the entire body. The toxins act specifically at the zona granulosa of the epidermis to produce the characteristic exfoliation, although the mechanism by which this is achieved is still poorly understood. Despite the availability of antibiotics, SSSS carries a significant mortality rate, particularly among neonates with secondary complications of epidermal loss and among adults with underlying diseases. The aim of this article is to provide a comprehensive review of the literature spanning more than a century and to cover all aspects of the disease. The epidemiology, clinical features, potential complications, risk factors, susceptibility, diagnosis, differential diagnoses, investigations currently available, treatment options, and preventive measures are all discussed in detail. Recent crystallographic data on the toxins has provided us with a clearer and more defined approach to studying the disease. Understanding their mode of action has important implications in future treatment and prevention of SSSS and other diseases, and knowledge of their specific site of action may provide a useful tool for physiologists, dermatologists, and pharmacologists.

Clinical Features and the Associated Factors of Staphylococcal Scalded Skin Syndrome during the Recent 10 Years

2008 ◽  
Vol 15 (2) ◽  
pp. 152 ◽  
Author(s):  
Chan Hee Park ◽  
Se Rin Na ◽  
Hyung Min Cho ◽  
Eun Jung Yoo ◽  
Kwon Jung ◽  
...  
Keyword(s):  
Clinical Features ◽  
Associated Factors ◽  
Staphylococcal Scalded Skin Syndrome

scholarly journals Distinguishing Features: Staphylococcal Scalded Skin Syndrome vs Toxic Epidermal Necrolysis

2018 ◽  
Vol 2 (2) ◽  
pp. 135-139 ◽  
Author(s):  
Hannah Roberts Badon ◽  
Joy King ◽  
Robert T Brodell ◽  
Adam Byrd
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Clinical Features ◽  
Supportive Therapy ◽  
Accurate Diagnosis ◽  
Careful Attention ◽  
Staphylococcal Scalded Skin Syndrome ◽  
Clinical Appearance ◽  
Distinguishing Features

Staphylococcal scalded skin syndrome (SSSS) and toxic epidermal necrolysis (TEN) are dermatologic conditions that have a similar clinical appearance.  Careful attention to clinical features, such as the coloration at the base of the blister, and histopathology are utilized to make an accurate diagnosis.  While supportive therapy is required for both conditions, SSSS requires appropriate antibiotics to treat the underlying staphylococcus and TEN requires elimination of an offending drug (usually an antibiotic).  

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