Tetracycline sun sensitivity

1966 ◽  
Vol 93 (1) ◽  
pp. 77-77 ◽  
Author(s):  
S. I. Cullen
Keyword(s):  
2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
A. I. Reeder ◽  
G. F. H. McLeod ◽  
A. R. Gray ◽  
R. McGee

Background. Sun-tanning perceptions are monitored to identify changes and help refine targeting of skin cancer prevention messages.Aim. To investigate associations between perceptions of sun-tanning and demographic factors among a New Zealand urban population, 1994–2006.Methods. A telephone survey series was conducted during summer in 1994, 1997, 1999/2000, 2002/2003, and 2005/2006. Demographic and personal information (sex, age group, skin sun-sensitivity, and self-defined ethnicity) obtained from 6,195 respondents, 50.2% female, 15–69 years, was investigated in relation to six sun-tanning related statements. A total “positive perceptions of tanning” (ProTan) score was also calculated. Regression analyses modelled each component and the ProTan score against survey year and respondent characteristics.Results. Statistically significantly higher ProTan scores were found for age group (strong reverse dose-response effect), male sex, residence (highest in Auckland), ethnicity (highest among Europeans), and sun sensitivity (ann-shaped association). There was no statistically significant change in total ProTan scores from baseline.Conclusions. The development, pretesting, and evaluation of messages for those groups most likely to endorse ProTan statements should be considered for the New Zealand skin cancer prevention program. To achieve and embed significant change, mass media campaigns may require greater intensity and reinforcement with sustained contextual support for settings-based behavioural change.


2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Chi-Bao Bui ◽  
Thao Thi Phuong Duong ◽  
Vien The Tran ◽  
Thuy Thanh T. Pham ◽  
Tung Vu ◽  
...  

AbstractXeroderma pigmentosum (XP) group D, a severe disease often typified by extreme sun sensitivity, can be caused by ERCC2 mutations. ERCC2 encodes an adenosine triphosphate (ATP)-dependent DNA helicase, namely XP group D protein (XPD). The XPD, one of ten subunits of the transcription factor TFIIH, plays a critical role in the nucleotide-excision repair (NER) pathway. Mutations in XPD that affect the NER pathway can lead to neurological degeneration and skin cancer, which are the most common causes of death in XP patients. Here, we present detailed phenotypic information on a Vietnamese family in which four members were affected by XP with extreme sun sensitivity. Genomic analysis revealed a compound heterozygous mutation of ERCC2 that affected family members and single heterozygous mutations in unaffected family members. We identified a novel, nonsense mutation in one allele of ERCC2 (c.1354C > T, p.Q452X) and a known missense mutation in the other allele (c.2048G > A, p.R683Q). Fibroblasts isolated from the compound heterozygous subject also failed to recover from UV-driven DNA damage, thus recapitulating aspects of XP syndrome in vitro. We describe a novel ERCC2 variant that leads to the breakdown of the NER pathway across generations of a family presenting with severe XP.


2018 ◽  
Vol 34 (6) ◽  
pp. 393-399 ◽  
Author(s):  
Alesia M. Jung ◽  
Leslie K. Dennis ◽  
Elizabeth T. Jacobs ◽  
Georg T. Wondrak

Author(s):  
Christopher Cunniff ◽  
Raoul C. Hennekam

Smith-Lemli-Opitz syndrome (SLOS) is characterized by prenatal and postnatal growth retardation, characteristic face, genital and distal limb anomalies, and intellectual disability. There is a weak correlation between the metabolic disturbances with clinical severity and with genotype, but wide ranges exist within each group. SLOS is infrequently described in adults. The associated malformations are usually treated in infancy and childhood and have only limited influences in adulthood. Main physical problems are scoliosis and pectus formation, sun sensitivity, and disturbed hearing and vision. Rarely adrenal insufficiency is present. Marked cognitive impairment and behavioral problems including self-harm and aggressive outbursts may have a significant impact on quality of life. Cholesterol supplementation decreases sun sensitivity, but cognition and behavior seem to respond less well.


Author(s):  
William L. Weston ◽  
Alfred T. Lane ◽  
Joseph G. Morelli
Keyword(s):  

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