Learned resourcefulness may be an important and necessary resource for people with diabetes to adequately manage their disease. This study used a cross-sectional, descriptive correlation design to examine the relationships of demographic characteristics, stressors, learned resourcefulness, and depressive symptoms among adult Taiwanese with diabetes mellitus. A convenience sample of 131 individuals recruited from outpatient primary care centers from two major hospitals in Taiwan participated in this study. Data were collected with a demographic questionnaire, blood tests, Rosenbaum’s self-control schedule, and the Center for Epidemiological Studies depression scale. Data analysis consisted of descriptive statistics and regression analysis. Findings suggest that individuals with diabetes who had greater learned resourcefulness and better glycemic control also had fewer depressive symptoms. In addition, learned resourcefulness partially mediated the relationship between glycemic control and depressive symptoms.