Lower Extremity Motor Evoked Potentials in Multiple Sclerosis

1991 ◽  
Vol 48 (9) ◽  
pp. 944-948 ◽  
Author(s):  
S. M. Jones ◽  
L. J. Streletz ◽  
V. E. Raab ◽  
R. L. Knobler ◽  
F. D. Lublin
Keyword(s):  
Multiple Sclerosis ◽  
Lower Extremity ◽  
Evoked Potentials ◽  
Motor Evoked Potentials

Predicting Hand Motor Recovery in Severe Stroke: The Role of Motor Evoked Potentials in Relation to Early Clinical Assessment

2008 ◽  
Vol 23 (1) ◽  
pp. 45-51 ◽  
Author(s):  
Annette A. van Kuijk ◽  
Jaco W. Pasman ◽  
Henk T. Hendricks ◽  
Machiel J. Zwarts ◽  
Alexander C. H. Geurts
Keyword(s):  
Lower Extremity ◽  
Evoked Potentials ◽  
Upper Extremity ◽  
Clinical Assessment ◽  
Predictive Value ◽  
Motor Evoked Potentials ◽  
Motor Recovery ◽  
Stroke Patients ◽  
Abductor Digiti Minimi

Objective. The primary aim of this study was to compare the predictive value of motor evoked potentials (MEPs) and early clinical assessment with regard to long-term hand motor recovery in patients with profound hemiplegia after stroke. Methods. The sample was an inception cohort of 39 stroke patients with an acute, ischemic, supratentorial stroke and an initial upper-extremity paralysis admitted to an academic hospital. Hand motor function recovery was defined at 26 weeks poststroke as a Fugl–Meyer Motor Assessment (FMA) hand score >3 points. The following prognostic factors were compared at week 1 and week 3 poststroke: motor functions as assessed by the FMA upper-extremity and lower-extremity subscores, and the presence of an MEP in the abductor digiti minimi and biceps brachii muscle. Results. Both the presence of an abductor digiti minimi–MEP and any motor recovery in the FMA upper-extremity subscore showed a positive predictive value of 1.00 at weeks 1 and 3. The FMA lower-extremity subscore showed the best negative predictive value (0.90; 95% CI 0.78-1.00 at week 1 and 0.95; 95% CI 0.87-1.00 at week 3). Conclusions. In stroke patients with an initial paralysis of the upper extremity the presence or absence of an MEP has similar predictive value compared with early clinical assessment with regard to long-term hand motor recovery.

Motor evoked potentials in a mouse model of chronic multiple sclerosis

2006 ◽  
Vol 33 (2) ◽  
pp. 265-273 ◽  
Author(s):  
Stefano Amadio ◽  
Stefano Pluchino ◽  
Elena Brini ◽  
Paolo Morana ◽  
Roberta Guerriero ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mouse Model ◽  
Evoked Potentials ◽  
Motor Evoked Potentials

Natalizumab restores evoked potential abnormalities in patients with relapsing–remitting multiple sclerosis

2010 ◽  
Vol 17 (2) ◽  
pp. 198-203 ◽  
Author(s):  
Sven G Meuth ◽  
Stefan Bittner ◽  
Carola Seiler ◽  
Kerstin Göbel ◽  
Heinz Wiendl
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Motor Evoked Potentials ◽  
Sum Score ◽  
Relapsing Remitting ◽  
Natalizumab Treatment ◽  
Remitting Multiple Sclerosis ◽  
Sum Scores ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis

Background and Objective: The objective of this study was to examine the effects of natalizumab on functional parameters assessed by evoked potentials (visual [VEP], somatosensory [SEP] and motor evoked potentials [MEP]) in a cohort study in relapsing–remitting multiple sclerosis patients. Methods: EP data of 44 patients examined 12 months prior to natalizumab treatment, at the timepoint of treatment initiation and 1 year later were compared. Sum scores (VEP, MEP, SEP) were evaluated and correlated with the Expanded Disability Status Scale. Results: Improvement of the VEP sum score was found in 33% of natalizumab-treated patients but only in 9% of the same patients prior to treatment ( p = 0.041). A comparable situation was found for SEP (improvement: 32% versus 5%; worsening: 11% versus 37%; p = 0.027). For MEP no significant differences were seen (improvement: 10% versus 18%; worsening: 5% versus 29%; p = 0.60). EP recordings (VEP = SEP > MEP) have the capacity to demonstrate treatment effects of natalizumab on a functional level. Conclusions: Natalizumab therapy increases the percentage of patients showing stable or even ameliorated electrophysiological parameters in the investigated functional systems.

Improvement in motor evoked potentials and clinical course post-steroid therapy in multiple sclerosis

1992 ◽  
Vol 108 (2) ◽  
pp. 184-188 ◽  
Author(s):  
J.Y. Salle ◽  
J. Hugon ◽  
F. Tabaraud ◽  
J.M. Boulesteix ◽  
J.M. Vallat ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Steroid Therapy ◽  
Clinical Course ◽  
Motor Evoked Potentials

scholarly journals Cortical Relay Time for Long Latency Reflexes in Patients with Definite Multiple Sclerosis

2004 ◽  
Vol 31 (2) ◽  
pp. 229-234 ◽  
Author(s):  
Cengiz Tataroglu ◽  
Ahmet Genc ◽  
Egemen Idiman ◽  
Raif Cakmur ◽  
Fethi Idiman
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Motor Evoked Potentials ◽  
Clinical Form ◽  
Control Subjects ◽  
Long Latency ◽  
Cortical Involvement ◽  
And Control ◽  
Long Latency Reflexes

AbstractBackground:Long latency reflexes (LLR) include afferent sensory, efferent motor and central transcortical pathways. It is supposed that the cortical relay time (CRT) reflects the conduction of central transcortical loop of LLR. Recently, evidence related to the cortical involvement in multiple sclerosis (MS) has been reported in some studies. Our aim was to investigate the CRT alterations in patients with MS.Methods:Upper extremity motor evoked potentials (MEP), somatosensory evoked potentials (SEP) and LLR were tested in 28 patients with MS and control subjects (n=22). The patients with MS were classified according to the clinical form (relapsing-remitting [R-R] and progressive groups). The MS patients with secondary progressive and primary progressive forms were considered as the “progressive” group. CRT for LLR was calculated by subtracting the peak latency of somatosensory evoked potentials (SEP) and that of motor evoked potentials (MEP) by transcranial magnetic stimulation from the onset latency of the second component of LLR (LLR2) (CRT = LLR2 – [MEP latency + N20 latency])Results:Cortical relay time was calculated as 7.4 ± 0.9 ms in control subjects. Cortical relay time was prolonged in patients with MS (11.2 ± 2.9 ms) (p<0.0001). The latencies of LLR, MEP and SEP were also prolonged in patients with MS. Cortical relay time was not correlated with disease severity and clinical form in contrast to other tests.Conclusions:Our findings suggested that CRT can be a valuable electrophysiological tool in patients with MS. Involvement of extracortical neural circuits between sensory and motor cortices or cortical involvement due to MS may cause these findings.

Intra-operative monitoring of lower extremity motor-evoked potentials by direct cortical stimulation

2012 ◽  
Vol 123 (6) ◽  
pp. 1248-1254 ◽  
Author(s):  
Yuichi Maruta ◽  
Masami Fujii ◽  
Hirochika Imoto ◽  
Sadahiro Nomura ◽  
Fumiaki Oka ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Evoked Potentials ◽  
Motor Evoked Potentials ◽  
Cortical Stimulation ◽  
Direct Cortical Stimulation ◽  
Operative Monitoring

Motor evoked potentials in clinically isolated syndrome suggestive of multiple sclerosis

2009 ◽  
Vol 15 (3) ◽  
pp. 355-362 ◽  
Author(s):  
A Rico ◽  
B Audoin ◽  
J Franques ◽  
A Eusebio ◽  
F Reuter ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Amplitude Ratio ◽  
Motor Evoked Potentials ◽  
Clinically Isolated Syndrome ◽  
Conduction Time ◽  
Motor Pathway ◽  
Clinical Sensitivity ◽  
Conduction Failure ◽  
Stimulation Technique

The aim of the present study was to determine the sensitivity and the profile of motor evoked potentials (MEP) in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS). We measured the central motor conduction time (CMCT), amplitude ratio (AR), and surface ratio (SR) in tibialis anterior and first dorsal interosseous muscles in 22 patients with CIS. In 12 patients, the triple stimulation technique (TST) was also performed. AR was abnormal in 50% of patients, CMCT in 18% of patients, and TST in 25% of patients. AR had the highest sub-clinical sensitivity and the best positive predictive value. In the absence of clinical pyramidal signs, an early AR decrease seems to result from demyelination inducing excessive temporal dispersion of the MEP, while in territories with clinical pyramidal signs, it seems to result from conduction failure, which suggests that clinical pyramidal signs may be attributable to conduction failure. This study demonstrates that MEP, especially the AR, is sensitive to motor pathway dysfunction right from the early stages of MS.

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